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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
力学研究所 [1]
金属研究所 [1]
地理科学与资源研究所 [1]
成都山地灾害与环境研... [1]
生态环境研究中心 [1]
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OAI收割 [24]
内容类型
期刊论文 [24]
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2024 [3]
2023 [3]
2022 [4]
2021 [4]
2020 [6]
2019 [3]
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学科主题
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浏览/检索结果:
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Targeting JMJD1C to selectively disrupt tumor T
reg
cell fitness enhances antitumor immunity
期刊论文
OAI收割
NATURE IMMUNOLOGY, 2024, 页码: 32
作者:
Long, Xuehui
;
Zhang, Sulin
;
Wang, Yuliang
;
Chen, Jingjing
;
Lu, Yanlai
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收藏
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浏览/下载:20/0
  |  
提交时间:2024/03/25
Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 2, 页码: 623-634
作者:
Xiong, Jiacheng
;
Cui, Rongrong
;
Li, Zhaojun
;
Zhang, Wei
;
Zhang, Runze
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收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Drug metabolism
Aldehyde oxidase
Transfer learning
Graph neural network
Kinase inhibitor
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
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收藏
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浏览/下载:10/0
  |  
提交时间:2024/02/27
Sequence-based drug design as a concept in computational drug design
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 21
作者:
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收藏
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浏览/下载:17/0
  |  
提交时间:2023/10/17
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214
作者:
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收藏
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浏览/下载:3/0
  |  
提交时间:2024/03/27
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3327-3347
作者:
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浏览/下载:2/0
  |  
提交时间:2024/03/27
A Review of the Hydraulic Fracturing in Ductile Reservoirs: Theory, Simulation, and Experiment
期刊论文
OAI收割
PROCESSES, 2022, 卷号: 10, 期号: 10, 页码: 26
作者:
Zhu,Dawei
;
Han GF(韩国锋)
;
Zou,Honglan
;
Cui,Mingyue
;
Liang,Chong
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收藏
  |  
浏览/下载:30/0
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提交时间:2022/11/21
hydraulic fracturing
ductile rock
plastic deformation
fracture toughness
fracture process zone
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5, 页码: 3923-3942
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Zhou, Zehui
;
Li, Yupeng
;
Cui, Rongrong
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收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/06/15
Evolution of Interfacial Microstructure of Ni-Co Base Superalloy During Plastic Deformation Bonding and Its Bonding Mechanism
期刊论文
OAI收割
ACTA METALLURGICA SINICA, 2022, 卷号: 58, 期号: 2, 页码: 129-140
作者:
Ren Shaofei
;
Zhang Jianyang
;
Zhang Xinfang
;
Sun Mingyue
;
Xu Bin
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收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/07/01
Ni-Co base superalloy
plastic deformation bonding
dynamic recrystallization
Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1, 页码: 103-119
作者:
Tan, Xiaoqin
;
Li, Chunpu
;
Yang, Ruirui
;
Zhao, Sen
;
Li, Fei
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收藏
  |  
浏览/下载:33/0
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提交时间:2022/06/15