中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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  • 上海药物研究所 [21]
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发表日期
  • 2019 [21]
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浏览/检索结果: 共21条，第1-10条 帮助

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Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
  |  收藏  |  浏览/下载：81/0  |  提交时间：2020/07/01
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease 期刊论文  OAI收割
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14
作者:  Zhang, Yu;  Wu, Qimei;  Zhang, Lei;  Wang, Qing;  Yang, Zexian
  |  收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression 期刊论文  OAI收割
CELL RESEARCH, 2019, 卷号: 29, 期号: 10, 页码: 787-803
作者:  Wang, Xinyi;  Sun, Guangqiang;  Feng, Teng;  Zhang, Jing;  Huang, Xun
  |  收藏  |  浏览/下载：84/0  |  提交时间：2020/07/01
Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1364-1372
作者:  Shi, Yi;  Wang, Ting;  Zhou, X. Edward;  Liu, Qiu-Feng;  Jiang, Yi
  |  收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01
Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging 期刊论文  OAI收割
CHEMICAL SCIENCE, 2019, 卷号: 10, 期号: 34, 页码: 7946-7951
作者:  Chen, Hao;  Wang, Jing;  Feng, Xin;  Zhu, Mark;  Hoffmann, Simon
  |  收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Identification of a new inhibitor of KRAS-PDE delta interaction targeting KRAS mutant nonsmall cell lung cancer 期刊论文  OAI收割
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 5, 页码: 1334-1345
作者:  Leung, Elaine Lai-Han;  Luo, Lian Xiang;  Li, Ying;  Liu, Zhong-Qiu;  Li, Lan Lan
  |  收藏  |  浏览/下载：32/0  |  提交时间：2020/07/01
Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP 期刊论文  OAI收割
EMBO JOURNAL, 2019, 页码: 18
作者:  Xu, Zhaowei;  Zhang, Hainan;  Zhang, Xingrun;  Jiang, Hewei;  Liu, Chengxi
  |  收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01
Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3229-3236
作者:  Duan, Zhe;  Liu, Jingqiu;  Niu, Liping;  Wang, Jun;  Feng, Mingqian
  |  收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593
作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian
  |  收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01
A Comprehensive Multilocus Sequence Typing Scheme for Identification and Genotyping of Staphylococcus Strains 期刊论文  OAI收割
FOODBORNE PATHOGENS AND DISEASE, 2019, 卷号: 16, 期号: 5, 页码: 331-338
作者:  Song, Minghui;  Li, Qiongqiong;  He, Yiping;  Lan, Lefu;  Feng, Zhen
  |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01