中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [27]
采集方式
OAI收割 [27]
内容类型
期刊论文 [27]
发表日期
2023 [27]
学科主题
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浏览/检索结果:
共27条,第1-10条
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发表日期:2023
专题:上海药物研究所
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Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12
作者:
Song, Zhaoxiang
;
Lu, Dan
;
Sun, Jun
;
Ye, Yangliang
;
Fang, Jiahui
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/01/16
GPR35
IBD
Lodoxamide
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Original Research Response to programmed cell death protein 1 antibody in patients with Epstein-Barr virus-associated intrahepatic cholangiocarcinoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF CANCER, 2023, 卷号: 194, 页码: 9
作者:
He, Wen-Zhuo
;
Huang, Yu-Hua
;
Hu, Wan-Ming
;
Wang, Fang
;
Xu, Yu-Xia
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/12/11
Epstein-Barr virus
Intrahepatic cholangiocarcinoma
Programmed cell death protein 1
Immunotherapy
Ligand activation mechanisms of human KCNQ2 channel
期刊论文
OAI收割
Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632
作者:
Ma, Demin
;
Zheng, Yueming
;
Li, Xiaoxiao
;
Zhou, Xiaoyu
;
Yang, Zhenni
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/03/26
Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2023, 卷号: 14, 期号: 21, 页码: 3941-3958
作者:
Ge, Haixia
;
Ji, Beihong
;
Fang, Jiahui
;
Wang, Jiayang
;
Li, Jing
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/11
function-based ligand design
receptor-ligandbinding profile
CB1/CB2
structure-activityrelationship
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease
期刊论文
OAI收割
WORLD JOURNAL OF PEDIATRICS, 2023, 页码: 12
作者:
Sun, Shu-Na
;
Zhou, Yan
;
Fu, Xing
;
Zheng, Yuan-Zheng
;
Xie, Cao
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/10/17
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2023, 卷号: 79, 期号: 3, 页码: 14
作者:
He, Fei
;
Jiang, Haowen
;
Peng, Chang
;
Wang, Tingting
;
Xiao, Rongrong
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2023/10/17
Glucuronyl C5-epimerase
Growth differentiation factor-15
Obesity
Energy expenditure
Ubiquitination