中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [97]
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Regulation of hippo signaling mediated apoptosis by
Rauvolfia tetraphylla
in triple-negative breast cancer
期刊论文
OAI收割
MEDICAL ONCOLOGY, 2024, 卷号: 41, 期号: 5, 页码: 14
作者:
Balavaishnavi, B.
;
Kamaraj, M.
;
Nithya, T. G.
;
Santhosh, P.
;
Gokilalakshmi, S.
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
Anti-proliferative effect
Hippo pathway
MDA-MB-231 cells
Apoptosis
Rauvolfia tetraphylla
Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia
期刊论文
OAI收割
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 13, 页码: 5027-5035
作者:
Shi, Yunkai
;
Liu, Minmin
;
Li, Mengna
;
Mao, Yiwen
;
Ma, Jingkun
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/05/07
Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 17
作者:
Pu, Congying
;
Li, Yize
;
Fu, Yixian
;
Yan, Yiyang
;
Tao, Siyao
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/02/27
AIM2 inflammasome
chemotherapy
gut microbiome
ileal epithelial cells
immune checkpoint blockade
lactobacillus
segmented filamentous bacterium
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
期刊论文
OAI收割
BMC CANCER, 2023, 卷号: 23, 期号: 1, 页码: 20
作者:
Ren, Ganglin
;
Li, Hongyan
;
Hong, Dan
;
Hu, Fangyu
;
Jin, Rongjia
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
LINC00955
Colorectal cancer
Cell cycle
CDK2
PHIP
Sp1
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2023, 页码: 20
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Lu, Wei
;
Zhu, Shulei
  |  
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2023/10/17
EGFR
HER2
NAMPT
Resistance
Selectivity
Molecular docking
Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2023, 页码: 10
作者:
Lin, Rongkun
;
Yang, Jie
;
Liu, Ting
;
Wang, Mingyu
;
Ke, Chongrong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
CDK9
cyclin T1
degrader
hydrophobic tag
protein degradation
Discovery of new small molecule inhibitors of the BPTF bromodomain
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 134, 页码: 106453
作者:
Liang, Xiaochen
;
Cao, Yu
;
Duan, Zhe
;
Wang, Mingchen
;
Zhang, Naixia
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
BPTF bromodomain
BPTF inhibitors
HTRF
c-Myc
Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 7, 页码: 4932-4951
作者:
Wang, Mingyu
;
Lin, Rongkun
;
Li, Jiacheng
;
Suo, Yuying
;
Gao, Jing
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis
期刊论文
OAI收割
METABOLOMICS, 2023, 卷号: 19, 期号: 2, 页码: 13
作者:
Zhang, Rong
;
Zhang, Zijia
;
Wu, Wenyong
;
Shi, Jingying
;
Berk, Entezar
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/04/10
Bufadienolides
Prostate cancer
Lipidomics
Transcriptomics
ELOVL6
PLD1