中国科学院机构知识库网格
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The Effects of Topiramate on Ethanol-Cocaine Interactions andDNA Methyltransferase Gene Expression in the Rat Prefrontal Cortex
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-39
作者:
V.Echeverry-Alzate
;
E. Gine
;
K. M. Bühler
;
J. Calleja-Conde
;
P. Olmos
  |  
收藏
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浏览/下载:332/0
  |  
提交时间:2017/07/24
Operant Ethanol Self-administration
Dnmt1 Corepressors
Histone deacetylase-2
Dual Dependence
Dna Methyltransferases
Addiction
Gene Expression
Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 14
作者:
Liu, Zhihao
;
Lin, Min
;
Liu, Chenyu
;
Chen, Xin
;
Chen, Qian
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收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/22
Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19
作者:
Chen, Yuting
;
Wang, Zekun
;
Zhang, Junjie
;
Shi, Qiongyu
;
Yang, Hong
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
PRMT5
Nucleoside derivatives
Methyltransferases
Structure -activity relationship
PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma
期刊论文
OAI收割
CANCER RESEARCH, 2024, 卷号: 84, 期号: 3, 页码: 419-433
作者:
Tao, Hongru
;
Jin, Chen
;
Zhou, Liyuan
;
Deng, Zhenzhong
;
Li, Xiao
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收藏
  |  
浏览/下载:16/0
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提交时间:2024/04/09
Chemical Inhibitors Targeting the Oncogenic m
6
A Modifying Proteins
期刊论文
OAI收割
ACCOUNTS OF CHEMICAL RESEARCH, 2023, 卷号: 56, 期号: 21, 页码: 3010-3022
作者:
Huang, Yue
;
Xia, Wenyang
;
Dong, Ze
;
Yang, Cai-Guang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
A patent review of PRMT5 inhibitors to treat cancer (2018-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2023, 页码: 28
作者:
Gao, Jing
;
Yang, Jie
;
Xue, Shengyu
;
Ding, Hong
;
Lin, Hua
  |  
收藏
  |  
浏览/下载:12/0
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提交时间:2023/10/17
PRMT5
inhibitor
epigenetic target
cancer treatment
combined treatment
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 1, 页码: 157-173
作者:
Sun, Mingming
;
Li, Leilei
;
Niu, Yujia
;
Wang, Yingzhi
;
Yan, Qi
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收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/27
Lung cancer
Metabolic reprogramming
Post-translational modification
PRMT6
Pentose phosphate pathway flux
Glycolysis
6-Phospho-gluconate dehydrogenase
a-enolase
ENO1
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555
作者:
Li, Ennian
;
Wang, Kai
;
Zhang, Bei
;
Guo, Siqi
;
Xiao, Senhao
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收藏
  |  
浏览/下载:37/0
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提交时间:2022/08/16
DNMT1 inhibitor
A549 cell lines
HCT116 cell lines
antitumor activity
pharmacokinetic
Proteomic characterization of post-translational modifications in drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 18
作者:
Zhai, Lin-hui
;
Chen, Kai-feng
;
Hao, Bing-bing
;
Tan, Min-jia
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/04/10
proteomics
protein post-translational modification
drug target
off-target
drug mechanism
precision medicine
Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations
期刊论文
OAI收割
JOURNAL OF MOLECULAR MODELING, 2022, 卷号: 28, 期号: 7, 页码: 184
作者:
Zhang, Qian
;
Zhang, Lun
;
Jin, Jia
;
Fan, Yaohua
;
Wang, Xiaoguang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/21
PRMT5
Small-molecule inhibitors
Virtual screening
Molecular docking
Molecular dynamics simulations