中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [564]
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Structurally diverse terpenoids and their DRAK2 inhibitory activities: A follow-up study on the vulnerable conifer Pseudotsuga forrestii
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1305, 页码: 13
作者:
Zhou, Peng-Jun
;
Huang, Ting
;
Ma, Guang-Lei
;
Zhao, Ze-Yu
;
Jiang, Zhe-Lu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/05/07
Pseudotsuga forrestii
Rare and endangered plants (REPs)
Triterpene-monoterpene hybrids
GLMDs
DRAK2 inhibition
Molecular docking
A strategy to boost xanthine oxidase and angiotensin converting enzyme inhibitory activities of peptides via molecular docking and module substitution
期刊论文
OAI收割
FOOD CHEMISTRY, 2024, 卷号: 442, 页码: 9
作者:
Meng, Pengfei
;
Wang, Yanxin
;
Huang, Yumeng
;
Liu, Tong
;
Ma, Mingxia
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
Peptide
Activity boosting strategy
Molecular docking
Module substitution
Xanthine oxidase inhibitory
Angiotensin-converting enzyme inhibitory
Discovery of novel SOS1 inhibitors using machine learning
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2024, 卷号: 15, 期号: 4, 页码: 1392-1403
作者:
Duo, Lihui
;
Chen, Yi
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
DockingGA: enhancing targeted molecule generation using transformer neural network and genetic algorithm with docking simulation
期刊论文
OAI收割
BRIEFINGS IN FUNCTIONAL GENOMICS, 2024, 页码: 12
作者:
Gao, Changnan
;
Bao, Wenjie
;
Wang, Shuang
;
Zheng, Jianyang
;
Wang, Lulu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/20
molecule generation
molecule optimization
drug discovery
deep learning
drug design
genetic algorithm
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
期刊论文
OAI收割
ELIFE, 2024, 卷号: 12, 页码: 35
作者:
Wu, Zhenyong
;
Kusick, Grant F.
;
Berns, Manon M. M.
;
Raychaudhuri, Sumana
;
Itoh, Kie
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
asynchronous release
short-term plasticity
synaptotagmin
zap-and-freeze
iGluSnFR
synaptic vesicle docking
Mouse
Atranorin inhibits Zika virus infection in human glioblastoma cell line SNB-19 via targeting Zika virus envelope protein
期刊论文
OAI收割
PHYTOMEDICINE, 2024, 卷号: 125, 页码: 11
作者:
Huang, Guan-gen
;
Wang, Hao-yu
;
Wang, Xiao-han
;
Yang, Tao
;
Zhang, Xiao-meng
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Zika virus
SNB-19 cells
Atranorin
Envelope protein
Entry stage
Antiviral drugs
A Novel Bifunctional Alginate Lyase and Antioxidant Activity of the Enzymatic Hydrolysates
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 卷号: 72, 期号: 8, 页码: 4116-4126
作者:
Gu, Xiaoqian
;
Fu, Liping
;
Wang, Zhiyan
;
Cao, Zhe
;
Zhao, Luying
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/04/07
bifunctional alginatelyase
alginate oligosaccharides
antioxidant activity
Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs
期刊论文
OAI收割
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6, 页码: 11
作者:
Wang, James Jiqi
;
Jin, Sanshan
;
Zhang, Heng
;
Xu, Youwei
;
Hu, Wen
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors