中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [52]
西北高原生物研究所 [9]
大连化学物理研究所 [4]
深圳先进技术研究院 [1]
新疆理化技术研究所 [1]
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OAI收割 [72]
内容类型
期刊论文 [70]
会议论文 [2]
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2023 [4]
2022 [4]
2021 [5]
2020 [2]
2019 [5]
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学科主题
Pharmacolo... [2]
物理化学 [2]
天然产物有机化学 [1]
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浏览/检索结果:
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Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease
期刊论文
OAI收割
FRONTIERS IN AGING NEUROSCIENCE, 2023, 卷号: 15, 页码: 20
作者:
Lyu, Yan
;
Wang, Yu
;
Guo, Jianyou
;
Wang, Yuqing
;
Lu, Yifan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/02
Corydalis Rhizoma
Alzheimer's disease
serum pharmacochemistry
network pharmacological
neuroinflammation
polarization type of BV2
JAK2/STAT3
Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 315, 页码: 11
作者:
Ye, Yaqing
;
Xue, Mingzhen
;
Tian, Xiaoting
;
Gao, Hongwei
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Anemoside B4
Pulsatilla chinensis
metabolite identification
Pharmacokinetics
Rectal suppository
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial
期刊论文
OAI收割
LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 卷号: 38, 页码: 13
作者:
Wang, Fuxiang
;
Xiao, Wen
;
Tang, Yimin
;
Cao, Mengli
;
Shu, Dan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
Covid-19
3CL protease inhibitor
SARS-CoV-2 viral load
Alleviation of COVID-19 symptoms
Ligand-modified nanocarriers for oral drug delivery: Challenges, rational design, and applications
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2022, 卷号: 352, 页码: 813-832
作者:
Zhang, Yaqi
;
Wang, Yaying
;
Li, Xiang
;
Nie, Di
;
Liu, Chang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/08
Ligand-modified nanocarriers
Transcytosis
Transporter
Active targeting
Oral drug delivery
Local drug delivery
Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-?B Ligand
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 16, 页码: 10992-11009
作者:
Yang, Kai
;
Li, Shunyao
;
Wang, Tianqi
;
Yan, Xueming
;
He, Qian
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/09/30
Dissecting the Regulation of Arachidonic Acid Metabolites by Uncaria rhynchophylla (Miq). Miq. in Spontaneously Hypertensive Rats and the Predictive Target sEH in the Anti-Hypertensive Effect Based on Metabolomics and Molecular Docking
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 12
作者:
Gao, Lei
;
Kong, Xinqin
;
Wu, Wenyong
;
Feng, Zijin
;
Zhi, Haijuan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/08/16
Uncaria
anti-hypertensive
arachidonic acid metabolites
sEH = soluble epoxide hydrolase
EETS
metabolomics
molecular docking
indole alkaloids
Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy br
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 6, 页码: 4818-4831
作者:
Wu, Shanchao
;
Huang, Yahui
;
Wang, Ting
;
Li, Keliang
;
Lu, Junjie
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收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/08/16
Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22, 页码: 16838-16853
作者:
  |  
收藏
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浏览/下载:30/0
  |  
提交时间:2022/06/15
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
  |  
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC