机构

• 上海药物研究所 [16]
• 化学研究所 [1]
• 上海生物化学与细胞生... [1]

采集方式

• OAI收割 [18]

内容类型

• 期刊论文 [18]

发表日期

• 2023 [2]
• 2022 [1]
• 2021 [3]
• 2008 [4]
• 2007 [2]
• 2006 [3]
• 更多

学科主题

• Biochemist... [2]
• Biotechnol... [1]
• Chemistry [1]

筛选

浏览/检索结果: 共18条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial 期刊论文  OAI收割 LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 卷号: 38, 页码: 13 作者:  Wang, Fuxiang;  Xiao, Wen;  Tang, Yimin;  Cao, Mengli;  Shu, Dan   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Covid-19  3CL protease inhibitor  SARS-CoV-2 viral load  Alleviation of COVID-19 symptoms   In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 231, 页码: 8 作者:  Xiong, Muya;  Nie, Tianqing;  Shao, Qiang;  Li, Minjun;  Su, Haixia   |  收藏  |  浏览/下载：21/0  |  提交时间：2022/06/15 SARS-CoV-2 3C-Like protease  Covalent inhibitor  Virtual screening  Crystal structure   A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo 期刊论文  OAI收割 VIRUSES-BASEL, 2021, 卷号: 13, 期号: 9, 页码: 1852 作者:  Van Dycke, Jana;  Dai, Wenhao;  Stylianidou, Zoe;  Li, Jian;  Cuvry, Arno   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/03/21 Caliciviridae  antivirals  small molecule  danio rerio  infection   Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12 作者:  Su, Haixia;  Yao, Sheng;  Zhao, Wenfeng;  Zhang, Yumin;  Liu, Jia   |  收藏  |  浏览/下载：57/0  |  提交时间：2021/08/17 What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2021, 页码: 34 作者:  Xiong, Muya;  Su, Haixia;  Zhao, Wenfeng;  Xie, Hang;  Shao, Qiang   |  收藏  |  浏览/下载：18/0  |  提交时间：2021/05/24 3C-like protease  binding modes  coronavirus  inhibitors  structure and function   Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 卷号: 56, 期号: 10, 页码: 1400-1405 作者:  Yang, Qiangang;  Chen, Lill;  He, Xuchang;  Gao, Zhenting;  Bai, Donglu   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 SARS coronavirus 3CL protease  cinanserin analogs  inhibitor  fluorescence resonance energy transfer-based assay   Residues on the dimer interface of SARS coronavirus 3C-like protease: Dimer stability characterization and enzyme catalytic activity analysis 期刊论文  OAI收割 JOURNAL OF BIOCHEMISTRY, 2008, 卷号: 143, 期号: 4, 页码: 525-536 作者:  Chen, Shuai;  Zhang, Jian;  Hu, Tiancen;  Chen, Kaixian;  Jiang, Hualiang   |  收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 catalytic mechanism  dimerization-activity relationship  dimer interface  residue-residue interactions  site-directed mutagenesis   Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease - Crystal structure with molecular dynamics simulations 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 卷号: 283, 期号: 1, 页码: 554-564 作者:  Chen, Shuai;  Hu, Tiancen;  Zhang, Jian;  Chen, Jing;  Chen, Kaixian   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease - Crystal structure with molecular dynamics simulations 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 卷号: 283, 期号: 1, 页码: 554-564 作者:  Chen, S;  Hu, T;  Zhang, J;  Chen, J;  Chen, K 收藏  |  浏览/下载：34/0  |  提交时间：2015/07/22