中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 12
作者:
Wu, Feifei
;
Sun, Jiaqi
;
Xu, Mingyang
;
Li, Huiyu
;
Wei, Jiarui
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/08/20
Macrocycle
Kinase
Inhibitors
HPK1
Cancer immunotherapy
Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 8
作者:
Chen, Yating
;
Liu, Qiupei
;
Meng, Xianghui
;
Cao, Wenxu
;
Duo, Lihui
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/08/20
SOS1 inhibitor
KRAS mutation
SOS1-KRAS interaction
Resistance
Molecularly imprinted polymer-based system for simultaneous fluorescence quantification of malachite green and crystal violet
期刊论文
OAI收割
MICROCHIMICA ACTA, 2025, 卷号: 192, 期号: 9, 页码: 15
作者:
Wei, Guo
;
Zhang, Yimeng
;
Wang, Rui
;
Wang, Chuanliang
;
Geng, Xuhui
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/10/13
Malachite green
Crystal violet
CdTe quantum dots
Molecularly imprinted polymers
Thin layer chromatography
Fluorescence determination
Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2025, 卷号: 36, 期号: 8, 页码: 7
作者:
Yang, Nana
;
Yuan, Rui
;
Fu, Xinyue
;
Tian, Xiao
;
Yu, Jin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/08/20
NDP-uronic acids
Biocatalysis
Enzyme-mediated biomimetic synthesis
Oxidation reaction insertion strategy
Sensitive and Facile Detection of Aloin via N,F-CD-Coated Test Strips Coupled with a Miniaturized Fluorimeter
期刊论文
OAI收割
BIOMOLECULES, 2025, 卷号: 15, 期号: 7, 页码: 14
作者:
Wei, Guo
;
Wang, Chuanliang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/10/14
aloin
nitrogen and fluorine-doped carbon dots (N,F-CDs)
test strips
fluorescence analysis
real samples
Integrative Proteomics and Histone PTMomics Study on Anti-TNBC Effect of JIB-04
期刊论文
OAI收割
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2025, 页码: 12
作者:
Tao, Shengna
;
Guo, Jingli
;
Zhang, Jingdan
;
Zhang, Mingya
;
Wang, Zhe
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/08/20
Proteomics
histone PTMomics
epigenetic inhibitor
JIB-04
TNBC
Covalent sortase A inhibitor, α, β-unsaturated aldehydes, prevents Staphylococcus aureus infection
期刊论文
OAI收割
MICROBIAL PATHOGENESIS, 2025, 卷号: 204, 页码: 12
作者:
Wang, Jianchao
;
He, Yuan
;
Chu, Chenliang
;
Wu, Ziqi
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2025/06/23
Sortase A
Covalent inhibitor
alpha
beta-unsaturated aldehydes
Anti-virulence therapy
Staphylococcus aureus
Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from
Lindera aggregata
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 235, 页码: 10
作者:
Li, Wen-Xian
;
Gan, Lu
;
Liao, Yi-Ling
;
Wu, Yu-Wei
;
Zhang, Bai-Hui
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2025/05/27
Lindera aggregata
Lauraceae
Lindenane sesquiterpenoid
Anti-hepatic fibrosis activity