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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [70]
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期刊论文 [185]
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Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 22
作者:
Guma, Samuel Desta
;
Zhou, Zhaoyin
;
Song, Kang
;
Yang, Feipu
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/12/11
SARS-CoV-2
3CL pro inhibitors
Peptidomimetics
Spiropyrrolidine derivatives
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:
Tang, Mingze
;
Zhou, Xuan
;
Shen, Qianqian
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/08/22
Receptor -interacting protein kinase 1
Histone deacetylases
Inhibitor
Molecular dynamics (MD) simulation
ADMET analysis
Direct Reductive
N
-alkylation of Amines with Carboxylic Esters
期刊论文
OAI收割
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 页码: 7
作者:
Zhang, Yuxuan
;
Bonku, Emmanuel Mintah
;
Yang, Xingbang
;
Zhu, Fuqiang
;
Jiang, Xiangrui
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/01/14
Direct reductive
N
-alkylation of amine
One-pot reaction
Grignard reagent
Amidation of ester
Cariprazine
Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents with Alkenyl Carbonate
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2024, 页码: 8
作者:
Qin, Hongjian
;
Yang, Xingbang
;
Mintah Bonku, Emmanuel
;
Zhu, Fuqiang
;
Abduahadi, Safomuddin
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/12/11
Iron catalysis
Alkylation of alkenyl carbonates
Grignard reagents
Cross-coupling reactions
C(
sp
2)-C(
sp
3) bonds formation
A review of the synthetic strategies toward the antiviral drug tecovirimat
期刊论文
OAI收割
ORGANIC & BIOMOLECULAR CHEMISTRY, 2024, 页码: 16
作者:
Bonku, Emmanuel Mintah
;
Qin, Hongjian
;
Odilov, Abdullajon
;
Abduahadi, Safomuddin
;
Guma, Samuel Desta
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/11/05
Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 111, 页码: 16
作者:
Li, Xiaomei
;
Zhang, Hui
;
Dong, Sanfeng
;
Gao, Xuejie
;
Sun, Haiguo
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/09/26
Multiple myeloma
1-amido-2-one-4-thio-deoxypyranose
TRIP13 inhibitor
In vivo activity
Structural Optimization of Isoquinoline Derivatives from Lycobetaine and Their Inhibitory Activity against Neuroendocrine Prostate Cancer Cells
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 18, 页码: 28
作者:
Zhang, Zhuo
;
Shen, Qianqian
;
Ji, Yiyi
;
Ma, Yanjie
;
Hou, Haiyang
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/11/05
NEPC
natural product
natural product derivatives
lycobetaine
A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19
作者:
Wang, Xiaoyan
;
Yun, Ying
;
Chen, Lili
;
Guo, Shimeng
;
Niu, Buying
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/07/12
Diabetes
GLP-1 receptor
Agonist
Structural optimization
Water molecule replacement
Structure activity relationship
Docking simulation
Impurity study of tecovirimat
期刊论文
OAI收割
HELIYON, 2024, 卷号: 10, 期号: 9, 页码: 12
作者:
Bonku, Emmanuel Mintah
;
Qin, Hongjian
;
Odilov, Abdullajon
;
Abduahadi, Safomuddin
;
Guma, Samuel Desta
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/08/20
Tecovirimat
Genotoxic impurities
Process development
International Conference on Harmonization
(ICH)
Quality control