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上海药物研究所 [74]
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期刊论文 [191]
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Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
CDK9
EZH2
Dual target inhibitor
DLBCL
The Intermediate-mass Black Hole Reverberation Mapping Project: First Detection of Mid-infrared Lags in Prototypical Intermediate-mass Black Holes in NGC 4395 and POX 52
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 989, 期号: 2
作者:
Sun, Jingbo
;
Guo, Hengxiao
;
Zuo, Wenwen
;
Lira, Paulina
;
Gu, Minfeng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/08/25
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18
作者:
Yang, Ruirui
;
Wang, Bei
;
Su, Zhaoming
;
Song, Ying
;
Zhang, Yingying
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
An Asymmetric Reductive Amination Synthesis of Ritlecitinib Using (
S
)-
α
-Methylbenzylamine as Chiral Auxiliary
期刊论文
OAI收割
CHEMISTRY-A EUROPEAN JOURNAL, 2025, 页码: 10
作者:
Dong, Hongkun
;
Bonku, Emmanuel Mintah
;
Zhang, Yuxuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/07/25
asymmetric reductive amination
chiral auxiliary
intramolecular amide formation
ritlecitinib
delta-lactam
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/04/01
Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 22
作者:
Guma, Samuel Desta
;
Zhou, Zhaoyin
;
Song, Kang
;
Yang, Feipu
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/12/11
SARS-CoV-2
3CL pro inhibitors
Peptidomimetics
Spiropyrrolidine derivatives
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:
Tang, Mingze
;
Zhou, Xuan
;
Shen, Qianqian
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/08/22
Receptor -interacting protein kinase 1
Histone deacetylases
Inhibitor
Molecular dynamics (MD) simulation
ADMET analysis
Direct Reductive
N
-alkylation of Amines with Carboxylic Esters
期刊论文
OAI收割
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 页码: 7
作者:
Zhang, Yuxuan
;
Bonku, Emmanuel Mintah
;
Yang, Xingbang
;
Zhu, Fuqiang
;
Jiang, Xiangrui
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/01/14
Direct reductive
N
-alkylation of amine
One-pot reaction
Grignard reagent
Amidation of ester
Cariprazine
Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents with Alkenyl Carbonate
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2024, 页码: 8
作者:
Qin, Hongjian
;
Yang, Xingbang
;
Mintah Bonku, Emmanuel
;
Zhu, Fuqiang
;
Abduahadi, Safomuddin
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/12/11
Iron catalysis
Alkylation of alkenyl carbonates
Grignard reagents
Cross-coupling reactions
C(
sp
2)-C(
sp
3) bonds formation