机构

• 上海药物研究所 [13]
• 化学研究所 [5]
• 植物研究所 [3]
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• OAI收割 [38]
• iSwitch采集 [1]

内容类型

• 期刊论文 [39]

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• 2024 [2]
• 2023 [5]
• 2022 [5]
• 2021 [4]
• 2020 [4]
• 2019 [1]
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学科主题

• Genetics &... [2]
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筛选

浏览/检索结果: 共39条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516 作者:  Xiong, Muya;  Nie, Tianqing;  Li, Zhewen;  Hu, Meiyi;  Su, Haixia   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/01/06 Isotopic insights and integrated analysis for heavy metal levels, ecological risks, and source apportionment in river sediments of the Qinghai-Tibet Plateau 期刊论文  OAI收割 ENVIRONMENTAL RESEARCH, 2024, 卷号: 251, 页码: 118626 作者:  Cai, Na;  Wang, Xueping;  Zhu, Haixia;  Hu, Yan;  Zhang, Xiying   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/06/17 Heavy metals  Sediment  Qinghai -Tibet plateau (QTP)  Potential ecological risk  Sources   Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：35/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay   Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches 期刊论文  OAI收割 CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696 作者:  Shao, Qiang;  Xiong, Muya;  Li, Jiameng;  Hu, Hangchen;  Su, Haixia   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/27 Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2 期刊论文  OAI收割 European journal of medicinal chemistry, 2023, 卷号: 249, 页码: 115129 作者:  Ren, Pengxuan;  Yu, Changyue;  Zhang, Ruxue;  Nie, Tianqing;  Hu, Qiaoyu   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/03/26 Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors 期刊论文  OAI收割 NATURE CHEMISTRY, 2023, 页码: 18 作者:  Guo, An-Di;  Yan, Ke-Nian   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/10/17 Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 207, 页码: 16 作者:  Gao, Jing;  Zhou, Chen;  Zhong, Yan;  Shi, Li;  Luo, Xuanyang   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/04/10 HSP90  ATP competitive inhibitors  Tip-based affinity selection-mass spectrometry  Dipyridamole  Cell cycle regulators   In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2 期刊论文  OAI收割 ANTIVIRAL RESEARCH, 2022, 卷号: 208, 页码: 10 作者:  Shang, Weijuan;  Dai, Wenhao;  Yao, Cheng;  Xu, Ling;  Tao, Xiangming   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/04/10 SARS-CoV-2  SARS-CoV-2 variants  FB2001  Main protease  PBPK  Anti-SARS-CoV-2 in vivo   Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10 作者:  Hu, Hangchen;  Wang, Qian;  Su, Haixia;  Shao, Qiang;  Zhao, Wenfeng   |  收藏  |  浏览/下载：26/0  |  提交时间：2023/04/10 Allosteric Modulator  Cysteine 270  Drug Design  Papain-Like Protease  SARS-CoV-2   Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7 作者:  Xiong, Yanchao;  Cheng, Fei;  Zhang, Junyi;  Su, Haixia;  Hu, Hangchen   |  收藏  |  浏览/下载：39/0  |  提交时间：2022/11/11 Zika virus  Fragment -based hit screening  Protein -inhibitor interactions  NS2B  NS3 protease  Crystal structure