中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [146]
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期刊论文 [385]
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Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 12
作者:
Wu, Feifei
;
Sun, Jiaqi
;
Xu, Mingyang
;
Li, Huiyu
;
Wei, Jiarui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Macrocycle
Kinase
Inhibitors
HPK1
Cancer immunotherapy
Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
CDK9
EZH2
Dual target inhibitor
DLBCL
Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from
Lindera aggregata
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 235, 页码: 10
作者:
Li, Wen-Xian
;
Gan, Lu
;
Liao, Yi-Ling
;
Wu, Yu-Wei
;
Zhang, Bai-Hui
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/27
Lindera aggregata
Lauraceae
Lindenane sesquiterpenoid
Anti-hepatic fibrosis activity
NMRExtractor: leveraging large language models to construct an experimental NMR database from open-source scientific publications
期刊论文
OAI收割
CHEMICAL SCIENCE, 2025, 卷号: 16, 期号: 25, 页码: 11548-11558
作者:
Wang, Qinggong
;
Zhang, Wei
;
Chen, Mingan
;
Li, Xutong
;
Xiong, Zhaoping
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Native Ligand-Inspired peptides for c-MET targeted PET probes development
期刊论文
OAI收割
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2025, 页码: 18
作者:
Luo, Renli
;
Tan, Boyu
;
Zhang, Ying
;
Hu, Jing
;
Lin, Jia
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
C-MET
Native ligand
HGF
PET/CT imaging
Radiopharmaceuticals
Peptide probes
Multiple flares and asymmetric broad emission lines in a recurring changing-look active galactic nucleus
期刊论文
OAI收割
ASTRONOMY & ASTROPHYSICS, 2025, 卷号: 698
作者:
Guo, Wei-Jian
;
Zhang, Zhi-Xiang
;
Moiseev, Alexei
;
Fawcett, Victoria A.
;
Chen, Yong-Jie
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/06/23
galaxies: active
galaxies: nuclei
quasars: supermassive black holes
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18
作者:
Yang, Ruirui
;
Wang, Bei
;
Su, Zhaoming
;
Song, Ying
;
Zhang, Yingying
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
Monitoring AGNs with Hβ Asymmetry. V. Long-term Variation and Evolution of the Broad Hβ Emission-line Profiles
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES, 2025, 卷号: 278, 期号: 2
作者:
Fang, Feng-Na
;
Du, Pu
;
Brotherton, Michael S.
;
McLane, Jacob N.
;
Zastrocky, T. E.
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/06/10
Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. XIV. Long-duration High-cadence Reverberation Mapping Results for 11 PG Quasars
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES, 2025, 卷号: 278, 期号: 2
作者:
Hu, Chen
;
Yao, Zhu-Heng
;
Chen, Yong-Jie
;
Songsheng, Yu-Yang
;
Wang, Yi-Lin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/06/23