中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
中国科学院大学 [3]
重庆绿色智能技术研究... [2]
上海营养与健康研究所 [2]
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沈阳应用生态研究所 [1]
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OAI收割 [16]
iSwitch采集 [3]
内容类型
期刊论文 [19]
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2025 [1]
2024 [1]
2023 [1]
2022 [3]
2021 [1]
2020 [2]
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Biotechnol... [1]
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浏览/检索结果:
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Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel
Hs
ClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
作者:
Sun, Mingyang
;
Chen, Beijing
;
Teng, Dan
;
Zhao, Hongshen
;
Liao, Yilie
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:
Chen, Beijing
;
Sun, Mingyang
;
Zhang, Chun
;
Huang, Qi
;
Teng, Dan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/12/25
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/02/19
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia
期刊论文
OAI收割
LEUKEMIA, 2022, 页码: 11
作者:
Jiang, Kailong
;
Li, Xuemei
;
Wang, Chang
;
Hu, Xiaobei
;
Wang, Peipei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/04/10
Malto-oligosaccharides as critical functional ingredient: a review of their properties, preparation, and versatile applications
期刊论文
OAI收割
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2022, 页码: 13
作者:
Ji, Hangyan
;
Liu, Jialin
;
McClements, David Julian
;
Bai, Yuxiang
;
Li, Zhitao
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/12/13
Malto-oligosaccharides
functional ingredient
physicochemical properties
enzymatic preparation
versatile applications
Targeted delivery and enhanced uptake of chemo-photodynamic nanomedicine for melanoma treatment
期刊论文
OAI收割
ACTA BIOMATERIALIA, 2022, 卷号: 147, 页码: 356-365
作者:
Huang, Xiaobei
;
Mu, Ning
;
Ding, Yuanfu
;
Lam, Hou Wang
;
Yue, Ludan
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/08/22
Photodynamic-chemotherapeutic therapy
Pt(IV) prodrug
Charge -reversal
Targeted drug delivery
Controlled drug release
Supramolecular micelles as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy
期刊论文
OAI收割
ACTA BIOMATERIALIA, 2021, 卷号: 131, 页码: 483-492
作者:
Huang, Xiaobei
;
Chen, Tunan
;
Mu, Ning
;
Lam, Hou Wang
;
Sun, Chen
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/10/13
Photodynamic-chemotherapeutic therapy
Supramolecular
Hypoxia-activated prodrug
Targeted drug delivery
Controlled drug release
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Biodegradation of mycotoxin fumonisin B1 by a novel bacterial consortium SAAS79
期刊论文
OAI收割
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 卷号: 103, 期号: 17, 页码: 7129-7140
作者:
Zhao, Zhiyong
;
Zhang, Yanmei
;
Chen, Shanshan
;
Zhao, Xiaoyan
;
Li, Xiaobei
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/09
Biodegradation
Fumonisin B1
Bacterial consortium
Enzymatic detoxification
Metabolites