中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
物理研究所 [12]
高能物理研究所 [6]
上海药物研究所 [5]
地理科学与资源研究所 [2]
合肥物质科学研究院 [2]
数学与系统科学研究院 [1]
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期刊论文 [32]
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2023 [1]
2022 [4]
2021 [2]
2020 [1]
2019 [2]
2016 [2]
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Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo
期刊论文
OAI收割
JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162
作者:
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Hao
;
Song, Peiran
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:120/0
  |  
提交时间:2023/04/10
fourth-generation EGFR inhibitor
EGFRC797S mutation
NSCLC
drug resistance
small molecular inhibitor
Climate drives the spatiotemporal dynamics of scrub typhus in China
期刊论文
OAI收割
GLOBAL CHANGE BIOLOGY, 2022, 页码: 11
作者:
Ding, Fangyu
;
Wang, Qian
;
Hao, Mengmeng
;
Maude, Richard James
;
Day, Nicholas Philip John
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/09/26
climate change
impacts
public health
scrub typhus
spatiotemporal dynamic
vector-borne disease
Climate drives the spatiotemporal dynamics of scrub typhus in China
期刊论文
OAI收割
GLOBAL CHANGE BIOLOGY, 2022, 页码: 11
作者:
Ding, Fangyu
;
Wang, Qian
;
Hao, Mengmeng
;
Maude, Richard James
;
Day, Nicholas Philip John
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/09/26
climate change
impacts
public health
scrub typhus
spatiotemporal dynamic
vector-borne disease
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations br
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:
Chen, Hao
;
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Yuqing
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/08/16
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:
Chen, Hao
;
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Yuqing
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/21
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
OAI收割
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
期刊论文
OAI收割
AUTOPHAGY, 2021, 卷号: 17
作者:
Klionsky, Daniel J.
;
Abdel-Aziz, Amal Kamal
;
Abdelfatah, Sara
;
Abdellatif, Mahmoud
;
Abdoli, Asghar
  |  
收藏
  |  
浏览/下载:318/0
  |  
提交时间:2021/05/31
Autophagosome
cancer
flux
LC3
lysosome
macroautophagy
neurodegeneration
phagophore
stress
vacuole
Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9
期刊论文
OAI收割
GENOME RESEARCH, 2020, 卷号: 30, 期号: 1, 页码: 118-126
作者:
Sun, Yonghua
;
Zhang, Bo
;
Luo, Lingfei
;
Shi, De-Li
;
Wang, Han
  |  
收藏
  |  
浏览/下载:124/0
  |  
提交时间:2020/05/13
Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms
期刊论文
OAI收割
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 19, 页码: 3428-3434
作者:
Ding, Cai-Feng
;
Zhang, Rong-Ping
;
Yu, Hao-Fei
;
Yang, Jing
;
Qin, Xu-Jie
  |  
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2019/11/07
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities