中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
化学研究所 [20]
上海药物研究所 [9]
过程工程研究所 [3]
中国科学院大学 [2]
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长春应用化学研究所 [2]
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期刊论文 [43]
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2024 [1]
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2018 [1]
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浏览/检索结果:
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Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 8
作者:
Zou, Wanyi
;
Li, Mengna
;
Wan, Shili
;
Ma, Jingkun
;
Lian, Linan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/09/26
acute leukemia
MDM2
oxidative phosphorylation
PRMT3
PROTAC
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11
作者:
Yang, Yun
;
Xiong, Yuan
;
Zhu, Guanghao
;
Sun, Mengru
;
Zou, Kun
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/10/17
Human carboxylesterase 2 (hCES2A)
Berberine analogues
Structure -activity relationships (SAR)
Inhibition kinetics
Selectivity
Targeting C/EBP alpha overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18
作者:
Wang, Hanlin
;
Luo, Guanghao
;
Hu, Xiaobei
;
Xu, Gaoya
;
Wang, Tao
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner
期刊论文
OAI收割
JOURNAL OF NANOBIOTECHNOLOGY, 2023, 卷号: 21, 期号: 1, 页码: 20
作者:
Wu, Guanghao
;
Su, Qihang
;
Li, Jie
;
Xue, Chao
;
Zhu, Jie
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2023/05/19
Extracellular vesicles
Adipose tissue-derived mesenchymal stem cells
NAD plus metabolism
Macrophage
Tendinopathy
Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 14
作者:
Sun, Haiguo
;
Xi, Mengyu
;
Jin, Qiang
;
Zhu, Zhengdan
;
Zhang, Yani
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/09/30
Discovery of a Potent and Selective Degrader for USP7
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395
作者:
Pei, Yuan
;
Fu, Jingfeng
;
Shi, Yunkai
;
Zhang, Mengmeng
;
Luo, Guanghao
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/21
Apoptotic Pathway
Mutant p53
p53 Mutant Cancer Cells
PROTAC
USP7 Degrader
Label-Free Detection and Translocation Dynamics Study of Single-Molecule Herceptin Using Solid-State Nanopores
期刊论文
OAI收割
ADVANCED MATERIALS TECHNOLOGIES, 2022
作者:
Hu, Rui
;
Lu, Wenlong
;
Wei, Guanghao
;
Nan, Hexin
;
Li, Juan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/12/23
solid-state nanopore
single-molecule detection
protein dynamics
monoclonal antibody
protein unfolding
Oligonucleotide Discrimination Enabled by Tannic Acid-Coordinated Film-Coated Solid-State Nanopores
期刊论文
OAI收割
LANGMUIR, 2022, 卷号: 38
作者:
Wei, Guanghao
;
Hu, Rui
;
Li, Qiuhui
;
Lu, Wenlong
;
Liang, Hanyu
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/12/23
Two‑stage hybrid network for segmentation of COVID‑19 pneumonia lesions in CT images: a multicenter study
期刊论文
OAI收割
Medical & Biological Engineering & Computing, 2022, 页码: 2721-2736
作者:
Yaxin Shang
;
Zechen Wei
;
Hui Hui
;
Xiaohu Li
;
Liang Li
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/06/28