中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [36]
近代物理研究所 [8]
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期刊论文 [100]
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Design, Synthesis, and Biological Evaluation of Peptidomimetic Tetrahydropyrrole Spirodihydroindolones as SARS-CoV-2 3CL Protease Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 16, 期号: 5, 页码: 790-796
作者:
Hu, Liuyan
;
Zhao, Zhi
;
Zhang, Shujing
;
Yang, Lei
;
Cui, Wenjie
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
COVID-19
SARS-CoV-2
3CL protease
Peptidomimetic inhibitors
Tetrahydropyrrole spirodihydroindolone
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling
期刊论文
OAI收割
CELL COMMUNICATION AND SIGNALING, 2025, 卷号: 23, 期号: 1, 页码: 19
作者:
Ren, Xiaojing
;
Teng, Yunfei
;
Xie, Kunxin
;
He, Xiao
;
Chen, Gang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/04/01
REG3A
Pancreatic ductal adenocarcinoma
Peritumoral acinar cell
Epidermal growth factor receptor (EGFR)
Paracrine
Identification of the VP37 pocket of monkeypox virus as a promising target for pan-orthopoxvirus inhibitors through virtual screening and antiviral assays
期刊论文
OAI收割
EMERGING MICROBES & INFECTIONS, 2024, 卷号: 13, 期号: 1, 页码: 4
作者:
Huo, Shuting
;
Wu, Leyun
;
Huang, Baoying
;
Liu, Nan
;
Sun, Jiewei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/08/22
Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 14
作者:
Li, Guanting
;
Hu, Yourong
;
Zhao, Han
;
Peng, Ziyu
;
Shang, Xin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/01/06
benzbromarone
drug-induced liver injury
drug metabolism
obesity
PPAR gamma
Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 111, 页码: 16
作者:
Li, Xiaomei
;
Zhang, Hui
;
Dong, Sanfeng
;
Gao, Xuejie
;
Sun, Haiguo
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/09/26
Multiple myeloma
1-amido-2-one-4-thio-deoxypyranose
TRIP13 inhibitor
In vivo activity
D3EGFR: a webserver for deep learning-guided drug sensitivity prediction and drug response information retrieval for EGFR mutation-driven lung cancer
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 3, 页码: 10
作者:
Shi, Yulong
;
Li, Chongwu
;
Zhang, Xinben
;
Peng, Cheng
;
Sun, Peng
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2024/05/07
lung cancer
EGFR mutation
drug sensitivity prediction
patient case database
deep learning
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11
作者:
Yang, Yun
;
Xiong, Yuan
;
Zhu, Guanghao
;
Sun, Mengru
;
Zou, Kun
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2023/10/17
Human carboxylesterase 2 (hCES2A)
Berberine analogues
Structure -activity relationships (SAR)
Inhibition kinetics
Selectivity
Plasma-enabled synthesis of ordered PtFe alloy nanoparticles encapsulated with ultrathin N-doped carbon shells for efficient methanol electrooxidation
期刊论文
OAI收割
NANO RESEARCH, 2022
作者:
Sun, Xuxu
;
Mao, Zhijian
;
Wang, Ruiqi
;
Pi, Xiaohu
;
Chen, Changle
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/12/22
methanol oxidation reaction
highly ordered PtFe alloy nanoparticles
ultrathin N-doped carbon shell
N-doped carbon support
plasma nanotechnology