中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 8
作者:
Chen, Yating
;
Liu, Qiupei
;
Meng, Xianghui
;
Cao, Wenxu
;
Duo, Lihui
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
SOS1 inhibitor
KRAS mutation
SOS1-KRAS interaction
Resistance
Diterpenoids and diarylheptanoids from the fruits of
Alpinia
zerumbet
and their anti-inflammatory activity
期刊论文
OAI收割
FITOTERAPIA, 2025, 卷号: 184, 页码: 10
作者:
Zhang, Zhenghan
;
Li, Guangqian
;
Luo, Xin
;
Xiao, Fang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Alpinia zerumbet
Labdane-type diterpenoid
Diarylheptanoid
Anti-inflammatory
ISG pathway
TDDFT ECD calculation
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 12, 页码: 12862-12880
作者:
Guo, Jing
;
Tang, Haotian
;
Zhao, Wenchao
;
Li, Yong
;
Song, Shukai
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Characterization of the Biological Effect Mediated by Mycobacterial Kinase PknG on Protein Phosphorylation and Acetylation
期刊论文
OAI收割
ACS OMEGA, 2025, 卷号: 10, 期号: 21, 页码: 21662-21673
作者:
Xie, Shuyu
;
Liu, Tianqi
;
Zhang, Luoxi
;
Yang, Yang
;
Tang, Yanqing
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/07/25
Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 15
作者:
Tang, Siyuan
;
Hu, Shuyang
;
Feng, Lijing
;
Kong, Linghui
;
Gui, Jiangwen
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/05/27
N-Cyclopropylmethyl-nornepenthones
Structure-activity relationship
MOR antagonist
KOR agonist
Substance use disorder
Online Alkaline-pH Reversed-Phase Nanoelectrospray-Tandem Mass Spectrometry Complements Traditional Phosphoproteomic Analysis via Influencing Charge State Distribution of Phosphopeptides
期刊论文
OAI收割
JOURNAL OF PROTEOME RESEARCH, 2025, 页码: 11
作者:
Wang, Yuqiu
;
Gao, Jing
;
Xie, Wenfan
;
Tang, Minchu
;
Chen, Xin
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/05/27
alkaline-pH-MS/MS
phosphoproteomics
chargestate
mass spectrometry
fractionation
A prominent oxygenation event in the late Mesoproterozoic broke the calm of the second half of the "Boring Billion"
期刊论文
OAI收割
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY, 2025, 卷号: 662, 页码: 13
作者:
Meng, Lin
;
Shi, Xiaoying
;
Zhou, Limin
;
Li, Jie
;
Liu, Wei
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2025/04/03
Ce anomaly
Mo isotope
Taizi Formation
Yemahe Formation
South China
I/(Ca plus Mg)
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20
作者:
Peng, Chang
;
Jiang, Haowen
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2025/04/01
Effects of doping on anti-phase boundaries and the magnetic properties of the D0
3
structure in high silicon steel: first-principles insights
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2025, 页码: 8
作者:
Sun, Meng
;
Li, Linxian
;
Song, Hongyu
;
Tang, Shuai
;
Peng Q(彭庆)
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2025/03/21
OpenClinicalAI: An open and dynamic model for Alzheimer's Disease diagnosis
期刊论文
OAI收割
EXPERT SYSTEMS WITH APPLICATIONS, 2025, 卷号: 261, 页码: 17
作者:
Huang, Yunyou
;
Liang, Xiaoshuang
;
Xie, Jiyue
;
Lu, Xiangjiang
;
Miao, Xiuxia
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/12/06
Real-world clinical setting
Alzheimer's disease
Diagnose
AI
Deep learning