中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
合肥物质科学研究院 [10]
广州地球化学研究所 [2]
上海技术物理研究所 [2]
南海海洋研究所 [1]
上海药物研究所 [1]
中国科学院大学 [1]
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OAI收割 [17]
iSwitch采集 [1]
内容类型
期刊论文 [18]
发表日期
2024 [2]
2023 [1]
2018 [3]
2017 [5]
2016 [5]
2006 [2]
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学科主题
Environmen... [1]
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浏览/检索结果:
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Spatial Distribution of Critical Metals and Chemostratigraphy in Co-Rich Ferromanganese Nodules in the Northwestern Pacific Ocean
期刊论文
OAI收割
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS, 2024, 卷号: 129, 期号: 10, 页码: 15
作者:
Ren, Jiangbo
;
Yang, Yong
;
Yu, Miao
;
Liu, Jiancheng
;
Luo, Shuaijie
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2025/04/01
mu-XRF
element mapping
high resolution
critical metal
ferromanganese nodule
northwestern Pacific Ocean
Effects of phosphatization on the mineralogical and geochemical composition of marine ferromanganese crusts from the JiaXie Guyot in the Western Pacific: Constraints from high resolution analysis
期刊论文
OAI收割
Ore Geology Reviews, 2024, 卷号: 172, 页码: 106209
作者:
Xianze Deng
;
Yonggang Liu
;
Jin-Cheng Luo
;
Gaowen He
;
Weibin Yang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/12/04
Absorption
phosphatization
marine Ferromanganese Crust
high-resolution Microanalysis
western Pacific
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 11
作者:
Cai, Haiyan
;
Wang, Yingying
;
Zhang, Jing
;
Wei, Zhenquan
;
Yan, Teng
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2023/10/17
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
  |  
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:
Wang, Beilei
;
Wu, Jiaxin
;
Wu, Yun
;
Chen, Cheng
;
Zou, Fengming
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2019/12/25
CDK9
Kinase inhibitor
Structure-activity relationship
Leukemia
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:
Wang, Qiang
;
Liu, Feiyang
;
Qi, Shuang
;
Qi, Ziping
;
Yan, Xiao-E.
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2019/06/10
PDGFR kinase
Type II inhibitor
Kinase inhibitor
CEL
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Wu, Hong
;
Qi, Ziping
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:
Chen, Yongfei
;
Wu, Jiaxin
;
Wang, Aoli
;
Qi, Ziping
;
Jiang, Taoshan
  |  
收藏
  |  
浏览/下载:1515/0
  |  
提交时间:2018/08/17
Egfr
Alk
Dual Kinase Inhibitor
Non-small Cell Lung Cancer
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:
Wang, Beilei
;
Deng, Yuanxin
;
Chen, Yongfei
;
Yu, Kailin
;
Wang, Aoli
  |  
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2018/08/16
Btk
Kinase Inhibitor
Irreversible Inhibitor
Structure-activity Relationship
B-cell Lymphoma
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125
作者:
Liang, Qianmao
;
Chen, Yongfei
;
Yu, Kailin
;
Chen, Cheng
;
Zhang, Shouxiang
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2018/07/26
Btk
Irreversible Inhibitor
Kinase Inhibitor
Structure-activity Relationship
B-cell Lymphoma