中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [44]
合肥物质科学研究院 [11]
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期刊论文 [97]
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The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase
期刊论文
OAI收割
BRITISH JOURNAL OF PHARMACOLOGY, 2023, 卷号: 180, 期号: 14, 页码: 1803-1818
作者:
Zhang, Jia
;
Li, Kai
;
Sun, Hao-Ran
;
Sun, Shao-Kun
;
Zhu, Ya-Ting
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
heparan sulfate mimetic
heparanase inhibitor
hepatic steatosis
lipoprotein lipase
obesity
A patent review of PRMT5 inhibitors to treat cancer (2018-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2023, 页码: 28
作者:
Gao, Jing
;
Yang, Jie
;
Xue, Shengyu
;
Ding, Hong
;
Lin, Hua
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
PRMT5
inhibitor
epigenetic target
cancer treatment
combined treatment
Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Zhan, Zhengsheng
;
Ji, Yinchun
;
Su, Haixia
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/04/10
Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11, 页码: 7854-7875
作者:
Rong, Deqin
;
Zhou, Kaixin
;
Fang, Wei
;
Yang, Hong
;
Zhang, Yi
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/08/16
Absorption, distribution, metabolism, and excretion of [C-14]TPN729 after oral administration to rats
期刊论文
OAI收割
XENOBIOTICA, 2022, 页码: 12
作者:
Cheng, Huan
;
Yu, Jinghua
;
Yang, Chen
;
Zhang, Ning
;
Fan, Zhen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15
TPN729
[C-14]TPN729
mass balance
tissue distribution
metabolism
Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 卷号: 17, 期号: 0, 页码: 3619-3632
作者:
Butnariu, Monica
;
Quispe, Cristina
;
Koirala, Niranjan
;
Khadka, Sujan
;
Salgado-Castillo, Carla Marina
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/09
MICROWAVE-ASSISTED EXTRACTION
ANTIRETROVIRAL THERAPY
BIOLOGICAL-ACTIVITIES
HIV-1 INTEGRASE
BREAST-CANCER
UP-REGULATION
NANOPARTICLES
DERIVATIVES
MECHANISMS
INHIBITION
Imbalance of TGF-beta 1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness
期刊论文
OAI收割
MOLECULAR THERAPY, 2021, 卷号: 29, 期号: 6, 页码: 2067-2087
作者:
Ning, Junya
;
Ye, Yingnan
;
Bu, Dechao
;
Zhao, Gang
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/12/01
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells
期刊论文
OAI收割
ARCHIVES OF PHARMACAL RESEARCH, 2021, 卷号: 44, 期号: 2
作者:
Li, Ming
;
Sun, Pengcheng
;
Dong, Kaikai
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/11/18
Chemerin
Human hepatic carcinoma SMMC7721 cells
Cell proliferation
Malignant phenotype
Cell differentiation
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects