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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [21]
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期刊论文 [86]
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Design and Synthesis Studies of α-Methylene-γ-butyrolactones Antagonists of GPR52
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 11, 页码: 3916-3929
作者:
Shen, Donghang
;
Li, Xin
;
Guo, Shimeng
;
Xie, Xin
;
Nan, Fajun
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/02/27
Huntingdon's disease
G protein-coupled receptor
GPR52
alpha-methylene-gamma-butyrolactones
antagonist
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 6, 页码: 1122-1134
作者:
Wang, Qing
;
Yao, Sheng
;
Yang, Ze-xian
;
Zhou, Chen
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/27
Parkinson's disease
alpha-synuclein aggregation
protein-protein interaction
03A10
MPTP/p model
enema inoculation model
Growth mechanism of alpha(p) and interface relationships between alpha(p) and alpha(s) during cooling of alpha near a titanium alloy
期刊论文
OAI收割
MATERIALS & DESIGN, 2022, 卷号: 223, 页码: 13
作者:
Jia, Runchen
;
Zeng, Weidong
;
Zhao, Zibo
;
Wang, Simin
;
Xu, Jianwei
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/05/09
Cooling rate
Epitaxial growth
Primary alpha(p)
Duplex microstructure
Secondary alpha(s)
Growth mechanism of alpha(p) and interface relationships between alpha(p) and alpha(s) during cooling of alpha near a titanium alloy
期刊论文
OAI收割
MATERIALS & DESIGN, 2022, 卷号: 223, 页码: 13
作者:
Jia, Runchen
;
Zeng, Weidong
;
Zhao, Zibo
;
Wang, Simin
;
Xu, Jianwei
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/05/09
Cooling rate
Epitaxial growth
Primary alpha(p)
Duplex microstructure
Secondary alpha(s)
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
作者:
Yang, Xiao-Tong
;
Li, Tian-Ze
;
Geng, Chang-An
;
Liu, Pei
;
Chen, Ji-Jun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/04/30
(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol
alpha-glucosidase inhibitors
PTP1B inhibitors
Enzyme kinetics
TYROSINE-PHOSPHATASE 1B
DIABETES-MELLITUS
EPIDEMIOLOGY
Multifunctional Anti-Alzheimer's Disease Effects of Natural Xanthone Derivatives: A Primary Structure-Activity Evaluation
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10, 页码: 842208
作者:
Hu, Xiaoyu
;
Liu, Chan
;
Wang, Kaichun
;
Zhao, Lanxue
;
Qiu, Yu
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/08/21
alpha-mangostin
Alzheimer's disease
multifunctional
structure-activity
neuroinflammation
amyloid beta
BETA-AMYLOID PEPTIDES
BLOOD-BRAIN-BARRIER
CENTRAL-NERVOUS-SYSTEM
ALPHA-MANGOSTIN
MICROGLIA
OLIGOMERS
AGGREGATION
MODULATION
PRODUCTS
DESIGN
New cembrane-type diterpenoids from the South China Sea soft coral Sinularia crassa and their alpha-glucosidase inhibitory activity
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2020, 卷号: 104, 页码: 6
作者:
Wu, Meng-Jun
;
Wang, Hong
;
Jiang, Cheng-Shi
;
Guo, Yue-Wei
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Sinularia crassa
Cembranoid
Modified Mosher's method
ECD calculation
alpha-Glucosidase inhibitor
Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 9
作者:
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/12/24
Soft coral
Sarcophyton ehrenbergi
Cembrane-type diterpenoids
Modified Mosher's method
ECD calculation
TNF-alpha inhibitory activity
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 4, 页码: 483-498
作者:
Xu, Ming-ming
;
Ryan, Philip
;
Rudrawar, Santosh
;
Quinn, Ronald J.
;
Zhang, Hai-yan
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
imaging probes
aggregation inhibitors
thioflavin-T
mass spectrometry
Identification of a New alpha-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 6, 页码: 2683-2691
作者:
Xu, Mingming
;
Loa-Kum-Cheung, Wendy
;
Zhang, Haiyan
;
Quinn, Ronald J.
;
Mellick, George D.
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
aggregation
mass spectrometry
screening
inhibitor