机构

• 上海药物研究所 [24]
• 金属研究所 [4]
• 昆明植物研究所 [3]
• 生态环境研究中心 [1]

采集方式

• OAI收割 [32]

内容类型

• 期刊论文 [31]
• 学位论文 [1]

发表日期

• 2020 [1]
• 2015 [2]
• 2012 [1]
• 2010 [1]
• 2009 [5]
• 2008 [4]
• 更多

学科主题

• Biochemist... [2]
• Chemistry,... [2]
• Neuroscien... [2]
• Behavioral... [1]
• Biophysics [1]
• Cell Biolo... [1]
• 更多

筛选

浏览/检索结果: 共32条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery and Biological Evaluation of New Selective Acetylcholinesterase Inhibitors with Anti-A beta Aggregation Activity through Molecular Docking-Based Virtual Screening 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 2, 页码: 161-166 作者:  Liu, Guangpu;  Jiao, Yang;  Lin, Yongqiang;  Hao, Haifang;  Dou, Yanli   |  收藏  |  浏览/下载：32/0  |  提交时间：2020/07/01 selective acetylcholinesterase inhibitor  amyloid beta aggregation  neuroprotectant  molecular docking  molecular dynamics simulation   Two new humulanolides from the roots of Cynanchum wilfordii 期刊论文  OAI收割 TETRAHEDRON LETTERS, 2015, 卷号: 56, 期号: 46, 页码: 6503-6505 作者:  Li, Jin-Long;  Fu, Yan;  Zhang, Hai-Yan;  Zhao, Wei-Min   |  收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 Humulanolides  Cynanchum wilfordii  Absolute configuration  Acetylcholinesterase inhibitor   Seven new Lycopodium alkaloids from the aerial parts of Phlegmariurus squarrosus 期刊论文  OAI收割 TETRAHEDRON, 2015, 卷号: 71, 期号: 33, 页码: 5308-5314 作者:  Li, Ping;  Huang, Wen;  Zhuo, Jingxian;  Guo, Zhiyong;  Cao, Wujisiguleng 收藏  |  浏览/下载：18/0  |  提交时间：2016/01/19 Lycopodium alkaloids  Phlegmariurus squarrosus  Lycopodiaceae  Structure elucidation  Acetylcholinesterase inhibitor   Design, synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo3,2-b-1, 2, 4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2012, 卷号: 23, 期号: 7, 页码: 765-768 作者:  Xu He Nan;  Jin Zhe;  Liu Si Jie;  Liu Hong Min;  Li Shuo   |  收藏  |  浏览/下载：10/0  |  提交时间：2021/02/26 ALZHEIMERS-DISEASE  Acetylcholinesterase inhibitor  Bromination  Heterocycle  Synthesis  7H-Thiazolo3,2-b-1, 2, 4-triazin-7-one derivatives   Synthesis and biological activity of 3,6-diaryl-7H-thiazolo3,2-b 1,2,4triazin-7-one derivatives as novel acetylcholinesterase inhibitors 期刊论文  OAI收割 SCIENCE CHINA-CHEMISTRY, 2010, 卷号: 53, 期号: 11, 页码: 2297-2303 作者:  Jin Zhe;  Yang Liu;  Xu HeNan;  Huang ErFang;  Wan David ChiCheong   |  收藏  |  浏览/下载：11/0  |  提交时间：2021/02/26 AMYLOID-BETA  ENZYME  DESIGN  acetylcholinesterase  inhibitor  thiazole  1,2,4-triazine  heterocycle  synthesis  docking  MVD   Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 7, 页码: 879-888 作者:  Wang, Juan;  Zhang, Hai-yan;  Tang, Xi-can   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 vascular dementia  cholinergic deficit  acetylcholinesterase inhibitor  inflammation   基于AChE多作用位点的氨基甲酸酯类和有机磷类化合物的设计、合成与生物活性测定 学位论文  OAI收割 博士, 北京: 中国科学院研究生院, 2009 赵前飞 收藏  |  浏览/下载：66/0  |  提交时间：2010/06/24 簇合效应原理  乙酰胆碱酯酶（AChE）  乙酰胆碱酯酶抑制剂（AChEI）  氨基甲酸酯类化合物  有机磷类化合物  离体活性  活体活性 cluster effect  acetylcholinesterase (AChE)  acetylcholinesterase inhibitor (AChEI)  carbamate compounds  organophosphorus compounds  activities in vitro  activities in vivo   Cholinergic deficiency involved in vascular dementia:possible mechanism and strategy of treatment 期刊论文  OAI收割 Acta Pharmacologica Sinica, 2009, 卷号: 30, 期号: 7, 页码: 879 作者:  Juan WANG;  Haiyan ZHANG;  Xican TANG   |  收藏  |  浏览/下载：131/0  |  提交时间：2020/07/01 NICOTINIC ACETYLCHOLINE-RECEPTORS  SPONTANEOUSLY HYPERTENSIVE-RATS  CHRONIC CEREBRAL HYPOPERFUSION  ATTENUATES COGNITIVE DEFICITS  L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE  ALZHEIMERS-DISEASE PATIENTS  OXYGEN-GLUCOSE DEPRIVATION  TRANSIENT GLOBAL-ISCHEMIA  HUPERZINE-A  DOUBLE-BLIND  vascular dementia  cholinergic deficit  acetylcholinesterase inhibitor  inflammation   Design, Synthesis, and Biological Evaluation of 5H-Thiazolo3,2-apyrimidine-6-carboxylic Acid Ethyl Ester Derivatives as a Novel Series of Acetylcholinesterase Inhibitors 期刊论文  OAI收割 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2009, 卷号: 25, 期号: 3, 页码: 332-337 作者:  Zhi Hui;  Chen Lanmei;  Zhang Linlin;  Liu Sijie;  Wan David Chi Cheong   |  收藏  |  浏览/下载：15/0  |  提交时间：2021/02/02 Acetylcholinesterase inhibitor  Docking screening  Heterocycle  Biological activity  5H-Thiazolo3,2-a pyrimidine-6-carboxylic acid ethyl ester derivative   Design, Synthesis, and Biological Evaluation of 5H-Thiazolo3,2-apyrimidine-6-carboxylic Acid Ethyl Ester Derivatives as a Novel Series of Acetylcholinesterase Inhibitors 期刊论文  OAI收割 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2009, 卷号: 25, 期号: 3, 页码: 332-337 作者:  Zhi Hui;  Chen Lanmei;  Zhang Linlin;  Liu Sijie;  Wan David Chi Cheong   |  收藏  |  浏览/下载：21/0  |  提交时间：2021/02/02 Acetylcholinesterase inhibitor  Docking screening  Heterocycle  Biological activity  5H-Thiazolo3,2-a pyrimidine-6-carboxylic acid ethyl ester derivative