机构

• 上海药物研究所 [46]
• 大连化学物理研究所 [5]
• 昆明植物研究所 [5]
• 金属研究所 [4]
• 西北高原生物研究所 [3]
• 过程工程研究所 [3]
• 更多

采集方式

• OAI收割 [84]

内容类型

• 期刊论文 [82]
• 学位论文 [2]

发表日期

• 2024 [5]
• 2023 [2]
• 2022 [7]
• 2021 [4]
• 2020 [6]
• 2019 [2]
• 更多

学科主题

• Oncology [3]
• Biochemist... [1]
• Biotechnol... [1]
• Chemistry,... [1]
• Chemistry,... [1]
• Engineerin... [1]
• 更多

筛选

浏览/检索结果: 共84条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16 作者:  Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 Proteasome inhibitors  Macrocycle  Stability  Anti-cancer activities   Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17 作者:  Zhuang, Zhen;  Miao, Yu-Ling;  Song, Shan-Shan;  Leng, Guang-Tong;  Zhang, Xiao-Fei   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/09/26 USP7 inhibitor  Structure-activity relationships  Anti-cancer  pyrrolo[2,3-d]pyrimidin-4-one   Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap 期刊论文  OAI收割 MOLECULES, 2024, 卷号: 29, 期号: 19, 页码: 26 作者:  Zhang, Han;  Shen, Qianqian;  Hu, Zhu;  Wu, Pei-Qian;  Chen, Yi   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/11/26 HDAC inhibitors  anti-cancer activity  natural products  pyrrole derivatives  molecular docking  molecular dynamics simulation   Resveratrol enhances the antiliver cancer effect of cisplatin by targeting the cell membrane protein PLA2 期刊论文  OAI收割 FRONTIERS IN ONCOLOGY, 2024, 卷号: 14 作者:  Gao, Yu;  Yang, Zhanyi;  Bajpai, Akhilesh Kumar;  Wang, Wenben;  Zhang, Liyuan   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/11/20 combination therapy  resveratrol  cisplatin  anti-liver cancer mechanism  cell membrane  PLA2   Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   A robust and validated LC-MS/MS method for the quantification of ramucirumab in rat and human serum using direct enzymatic digestion without immunoassay 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2024, 卷号: 1234, 页码: 11 作者:  Huang, Wen-si;  Li, Wei-qiang;  Yu, Xiong;  Xue, Ming-zhen;  Yuan, Ya-li   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/04/09 Anti -gastric cancer monoclonal antibody  Ramucirumab  LC -MS/MS  Method validation  Surrogate peptide   Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica 期刊论文  OAI收割 PHYTOCHEMISTRY, 2023, 卷号: 213, 页码: 11 作者:  Li, Jia-yuan;  Wu, Shi-fei;  An, Ya-ling;  Yao, Chang-liang;  Yao, Shuai   |  收藏  |  浏览/下载：36/0  |  提交时间：2023/10/17 Fritillaria sinica  Liliaceae  Zhonghuabeimu  Steroidal alkaloid derivatives  Anti -cancer effect  Anti -oxidation  Anti -inflammation   Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, 卷号: 19, 期号: 6, 页码: 1698-1712 作者:  Zhang, Meng;  Liu, Ergang;  Chen, Guihua;  Tang, Yisi;  Fang, Yuefei   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17 Trichosanthin  cell -penetrating peptide  anti -PD-1 therapy  tumor immune microenvironment  colorectal cancer   Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10 作者:  Jia, Xiao-min;  Long, Yi-ru;  Yu, Xiao-lu;  Chen, Run-qiu;  Gong, Li-kun   |  收藏  |  浏览/下载：24/0  |  提交时间：2023/04/10 cancer immunotherapy  CMTM6  CMTM6  PD-L1 complex  protein interactions  anti-CMTM6 nanobody   S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71 作者:  Li, Haobin;  Cai, Maohua;  Cao, Fei;  Yu, Dehua;  Yang, Jing   |  收藏  |  浏览/下载：29/0  |  提交时间：2022/12/22 STAT3 inhibitor  Quinone derivative  S3I-201  Anti -gastric cancer drug