中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
计算技术研究所 [4]
武汉病毒研究所 [3]
自动化研究所 [3]
合肥物质科学研究院 [3]
生物物理研究所 [1]
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OAI收割 [22]
iSwitch采集 [4]
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期刊论文 [25]
会议论文 [1]
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2025 [1]
2024 [3]
2023 [2]
2022 [5]
2021 [2]
2020 [2]
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学科主题
Biochemist... [1]
Biology [1]
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Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 15, 页码: 9
作者:
Jiang, Mengting
;
Xu, Youwei
;
Luan, Xiaodong
;
Wu, Kai
;
Li, Zhen
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/06/23
G protein-coupled receptor
cryo-electron microscopy
cysteinyl leukotriene receptor2
activation mechanism
G alpha q protein coupling
Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 11, 页码: 5069-5073
作者:
Li, Jie
;
Li, Guanyi
;
Mai, Yiting
;
Liu, Xiao
;
Yang, Dehua
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/01/06
GLP-1(9-36)
Cryo-electron microscopy
Metabolite
Allosteric modulation
DeepETPicker: Fast and accurate 3D particle picking for cryo-electron tomography using weakly supervised deep learning
期刊论文
OAI收割
Nature Communications, 2024, 卷号: 15, 期号: 1, 页码: 2090
作者:
Guole Liu
;
Tongxin Niu
;
Mengxuan Qiu
;
Yun Zhu
;
Fei Sun
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2024/06/11
Cryo-electron tomography
particle picking
deep learning
weakly supervised learning
Nanobodies as negative allosteric modulators for human calcium sensing receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9
作者:
Cui, Qianqian
;
Wang, Lu
;
Wang, Haonan
;
Chen, Xiaochen
;
Han, Li
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2024/04/09
G-protein-coupled receptor
Extracellular calcium sensing receptor
Nanobody
Cryo-electron microscope
Systemic Ca 2+homoeostasis
Structural analysis of the dual agonism at GLP-1R and GCGR
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 33, 页码: 12
作者:
Li, Yang
;
Zhou, Qingtong
;
Dai, Antao
;
Zhao, Fenghui
;
Chang, Rulue
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/05/07
glucagon-like peptide-1 receptor
glucagon receptor
cryo-electron microscopy
dual agonism
Cryo-electron microscopy structure of the intact photosynthetic light-harvesting antenna-reaction center complex from a green sulfur bacterium
期刊论文
OAI收割
JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2023, 卷号: 65, 期号: 1, 页码: 223-234
作者:
Chen, Jing-Hua
;
Wang, Weiwei
;
Wang, Chen
;
Kuang, Tingyun
;
Shen, Jian-Ren
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/03/07
cryo-electron microscopy
energy transfer
FMO protein
green sulfur bacterium
photosynthesis
reaction center
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 11
作者:
Zhao, Li-hua
;
Yuan, Qing-ning
;
Dai, An-tao
;
He, Xin-heng
;
Chen, Chuan-wei
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2023/04/10
G protein- coupled receptors
parathyroid hormone
PTH-related peptide
PTH receptor-1
cryo-electron microscopy structure
osteoporosis
Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br
期刊论文
OAI收割
NANO LETTERS, 2022, 卷号: 22
作者:
Song, Yongxiu
;
Dai, Bin
;
Wang, Yong
;
Wang, Yin
;
Liu, Cong
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2023/01/10
peptide self-assembly
atomic force microscopy
cryo-electron microscopy (cryo-EM)
hierarchical nanostructure
twisted nanofibrils
Fast Particle Picking for Cryo-Electron Tomography Using One-Stage Detection
会议论文
OAI收割
Kolkata, India, 2022-3
作者:
Wu SY(吴诗雨)
;
Liu GL(刘国乐)
;
Yang G(杨戈)
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/06/17
Particle picking
Cryo-electron tomography
Object detection
Deep learning
Convolutional neural network
Machine Learning for Structure Determination in Single-Particle Cryo-Electron Microscopy: A Systematic Review
期刊论文
OAI收割
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2022, 卷号: 33, 期号: 2, 页码: 452-472
作者:
Wu, Jia-Geng
;
Yan, Yang
;
Zhang, Dong-Xu
;
Liu, Bo-Wen
;
Zheng, Qing-Bing
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/03/17
Machine learning
Periodic structures
Task analysis
Proteins
Photomicrography
Coronaviruses
Machine learning algorithms
Clustering
deep learning (DL)
image processing
machine learning
neural network (NN)
single-particle cryo-electron microscopy (cryo-EM)