中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [6]
大连化学物理研究所 [4]
昆明植物研究所 [2]
中国科学院大学 [1]
武汉植物园 [1]
沈阳应用生态研究所 [1]
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OAI收割 [15]
iSwitch采集 [1]
内容类型
期刊论文 [16]
发表日期
2023 [1]
2021 [1]
2020 [1]
2018 [2]
2017 [1]
2016 [2]
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学科主题
Chemistry,... [1]
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Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
OAI收割
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 卷号: 14, 页码: 1963-1970
作者:
Zhu, Yun-Ting
;
Teng, Zan
;
Zhang, Yi-Fan
;
Li, Wei
;
Guo, Li-Xia
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
apatinib
drug-drug interaction
CYP3A4
CYP2C9
nifedipine
warfarin
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 8, 页码: 1386-1392
作者:
Xu, Ye
;
Zhang, Yi-fan
;
Chen, Xiao-yan
;
Zhong, Da-fang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
triptolide
(5R)-5-hydroxytriptolide
CYP3A4
ritonavir
dexamethasone
pharmacokinetics
immunosuppressant
traditional Chinese medicine
Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 3, 页码: 344-350
作者:
Qian, Anran
;
Zheng, Yazhou
;
Wang, Ruilian
;
Wei, Jianhai
;
Cui, Yongmei
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Triazoles
Antifungal activity
Drug-drug interactions
Tetrazole
CYP3A4
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis
期刊论文
OAI收割
FITOTERAPIA, 2017, 卷号: 119, 页码: 26-31
作者:
Zhao, Jin
;
Sun, Tao
;
Wu, Jing-Jing
;
Cao, Yun-Feng
;
Fang, Zhong-Ze
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2017/10/29
Gomisin c
Gomisin g
Cyp3a4
Cyp3a5
Inhibition
Herb-drug Interactions
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
iSwitch采集
Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/05/09
Pyrotinib
Uplc/q-tof ms
Metabolism
Human
Cyp3a4
Drug-drug interaction
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Pyrotinib
UPLC/Q-TOF MS
Metabolism
Human
CYP3A4
Drug-drug interaction
A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4
期刊论文
OAI收割
international journal of molecular sciences, 2015, 卷号: 16, 期号: 7, 页码: 14677-14694
作者:
Dai, Zi-Ru
;
Ai, Chun-Zhi
;
Ge, Guang-Bo
;
He, Yu-Qi
;
Wu, Jing-Jing
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2015/11/17
CYP3A4
steroids
metabolic site
mechanism-based prediction
activation energy
Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
期刊论文
OAI收割
FOOD CHEMISTRY, 2013, 卷号: 141, 期号: 2, 页码: 920-926
作者:
Peng, Xing-Rong
;
Liu, Jie-Qing
;
Han, Zhong-Hui
;
Yuan, Xiao-Xi
;
Luo, Huai-Rong
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2013/10/16
Ganoderma resinaceum
Ganoderma triterpenoids
Hepatoprotective activities
CYP3A4
HepG2 cells