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浏览/检索结果: 共1337条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 20 作者:  Miao, Yunqiu;  Li, Lijun;  Wang, Ying;  Wang, Jiangyue;  Zhou, Yihan   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/13 Nanobodies as negative allosteric modulators for human calcium sensing receptor 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9 作者:  Cui, Qianqian;  Wang, Lu;  Wang, Haonan;  Chen, Xiaochen;  Han, Li   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/04/09 G-protein-coupled receptor  Extracellular calcium sensing receptor  Nanobody  Cryo-electron microscope  Systemic Ca 2+homoeostasis   Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14 作者:  Chen, Xuetao;  Wu, Tingting;  Du, Zhiyan;  Kang, Wenjing;  Xu, Rujun   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/02/27 BET  BD1  Bromodomain  Brain-permeable  Multiple sclerosis   Discovery of GPX4 inhibitors through FP-based high-throughput screening 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14 作者:  Cao, Yu;  Wu, Bin;  Xu, Ying;  Wang, Mingchen;  Wu, Xinyu   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/02/27 GPX4 inhibitor  HTS assay  Ferroptosis  Fluorescence polarization   JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Platanosides from Platanus x acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9 作者:  Wu, Xi-Ying;  Zhao, Ze-Yu;  Osman, Ezzat E. A.;  Wang, Xiao-Juan;  Choo, Yeun-Mun   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/06 Platanus x acerifolia  Platanosides  Molecular ion networking (MoIN)  Antibacterial  Staphylococcus aureus  Enterococcus faecium  Structure -activity relationship (SAR)  Molecular docking  Target validation   Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding 期刊论文  OAI收割 BRITISH JOURNAL OF PHARMACOLOGY, 2024, 页码: 17 作者:  Li, Zhi;  Wu, Ning;  Wang, Jing;  Yue, Yang;  Geng, Lihua   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/04/07 diabetic vascular complication  glycocalyx  insulin resistance  LMWF  NEU2   The emergence of machine learning force fields in drug design 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2024, 页码: 36 作者:  Chen, Mingan;  Jiang, Xinyu;  Zhang, Lehan;  Chen, Xiaoxu;  Wen, Yiming   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/02/19 computational chemistry  drug design  force field  machine learning  molecular modeling   Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/02/19 Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12 作者:  Zhao, Tian-Tian;  Hu, Hao-Jie;  Gao, Li-Xin;  Zhou, Yu-Bo;  Zhu, Yun-Long   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Protein tyrosine phosphatases inhibitors  PTP1B inhibitors  Mechanism study  Molecular dynamics