中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [132]
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Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 119, 页码: 36
作者:
Wang, Han
;
Ma, Xiaolong
;
Sun, Longkang
;
Bi, Tongyu
;
Yang, Weibo
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/04/01
Synthetic methodologies
Medicinal chemistry
New chemical reactions
Anticancer drug discovery
Synchrotron Radiation: A Key Tool for Drug Discovery
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 114, 页码: 10
作者:
Li, Fengcheng
;
Liu, Runze
;
Li, Wenjun
;
Xie, Mingyuan
;
Qin, Song
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/12/06
Synchrotron radiation
Drug discovery
Protein crystals
Structure determination
Ligand screening
Synchrotron Radiation: A Key Tool for Drug Discovery
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 114, 页码: 10
作者:
Li, Fengcheng
;
Liu, Runze
;
Li, Wenjun
;
Xie, Mingyuan
;
Qin, Song
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/06
Synchrotron radiation
Drug discovery
Protein crystals
Structure determination
Ligand screening
Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2024, 页码: 27
作者:
Zang, Yi
;
Sun, Ruo-nan
;
Feng, Ran-qi
;
Zhu, Hong-hui
;
Li, Xu-wen
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/25
Natural products
Terpenoids
Novel structures
Biological activity
Drug discovery
An updated patent review of SOS1 inhibitors (2022-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15
作者:
Zhou, Guizhen
;
Zhou, Chuan
;
Ma, Xinyi
;
Xu, Jiahang
;
Zhou, Zehui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/12/11
SOS1
KRAS
cancer
inhibitor
drug discovery
The application of nanodiscs in membrane protein drug discovery & development and drug delivery
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2024, 卷号: 12
作者:
Dong, Yingkui
;
Tang, Huan
;
Dai, Han
;
Zhao, Hongxin
;
Wang, Junfeng
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/11/20
nanodisc (ND)
membrane protein
drug discovery & development
drug delievery
membrane scaffold protein (MSP)
Unlocking the geochemical features of the Paleocene southern Pacific Ocean using carbon isotopes and biolipids
期刊论文
OAI收割
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY, 2024, 卷号: 650, 页码: 13
作者:
Jiang, Lian
;
Ausin, Blanca
;
Khanolkar, Sonal
;
Wang, Yunpeng
;
George, Simon C.
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/13
International Ocean Discovery Program (IODP)
Expedition 378
Hopanoid
Steroid
New Zealand
Population Genetics Analysis and Sex GWAS of
Hemicentrotus pulcherrimus
期刊论文
OAI收割
RUSSIAN JOURNAL OF GENETICS, 2024, 卷号: 60, 期号: 8, 页码: 1063-1069
作者:
Li, X.
;
Ji, H.
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/10/24
Hemicentrotus pulcherrimus
SNP discovery
genetic diversity
population structure
China seas
An Intelligent Fault Diagnosis Framework for Rolling Bearings With Integrated Feature Extraction and Ordering-Based Causal Discovery
期刊论文
OAI收割
IEEE SENSORS JOURNAL, 2024, 卷号: 24, 期号: 10, 页码: 16374-16386
作者:
Ding, Xu
;
Wang, Junlong
;
Wu, Hao
;
Xu, Juan
;
Xin, Miao
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/09/09
Fault diagnosis
Feature extraction
Vibrations
Deep learning
Rolling bearings
Data models
Sensors
Causal discovery
causal effect
diagnosis framework
feature extraction
rolling bearing
DockingGA: enhancing targeted molecule generation using transformer neural network and genetic algorithm with docking simulation
期刊论文
OAI收割
BRIEFINGS IN FUNCTIONAL GENOMICS, 2024, 页码: 12
作者:
Gao, Changnan
;
Bao, Wenjie
;
Wang, Shuang
;
Zheng, Jianyang
;
Wang, Lulu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/20
molecule generation
molecule optimization
drug discovery
deep learning
drug design
genetic algorithm