中国科学院机构知识库网格系统: 检索

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	The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文 OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者: Liang, Xuewu; Ren, Hairu; Han, Fengyang; Liang, Renwen; Zhao, Jiayan \| 收藏 \| 浏览/下载：20/0 \| 提交时间：2024/01/16 chimeric design degradation System PROTAC targeted degradation technology undruggable targets
	Stimuli-activatable PROTACs for precise protein degradation and cancer therapy 期刊论文 OAI收割 SCIENCE BULLETIN, 2023, 卷号: 68, 期号: 10, 页码: 1069-1085 作者: Gao, Jing; Yang, Lei; Lei, Shumin; Zhou, Feng; Nie, Huijun \| 收藏 \| 浏览/下载：8/0 \| 提交时间：2023/10/17 PROTAC Stimuli-activatable prodrug Precise protein degradation Nanomedicine Combinatory therapy
	Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文 OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者: Li, Hui-yu; Qi, Wei-liang; Wang, Yu-xiang; Meng, Ling-hua \| 收藏 \| 浏览/下载：117/0 \| 提交时间：2023/10/17 Biomarkers Covalent KRasG12Cinhibitors Drug resistance Human cancers KRASG12Cmutation
	Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads 期刊论文 OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2608-2621 作者: Wang, Jingyao; Zhou, Shaoqing; Cheng, Yan; Cheng, Lin; Qin, Ying \| 收藏 \| 浏览/下载：3/0 \| 提交时间：2024/03/27
	A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function 期刊论文 OAI收割 CELL REPORTS PHYSICAL SCIENCE, 2022, 卷号: 3, 期号: 10, 页码: 12 作者: Xu, Yan; Fu, Dingqiang; Yuan, Yi; Peng, Yan; Dong, Juan \| 收藏 \| 浏览/下载：15/0 \| 提交时间：2023/04/10
	Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives 期刊论文 OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 28 作者: Li, Jiao; Cai, Zhenyu; Li, Xu-Wen; Zhuang, Chunlin \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2022/12/13
	Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion 期刊论文 OAI收割 ADVANCED SCIENCE, 2020, 页码: 13 作者: Sun, Zhongya; Zhang, Hao; Zhang, Yuanyuan; Liao, Liping; Zhou, Wen \| 收藏 \| 浏览/下载：77/0 \| 提交时间：2020/07/01 anti-metastasis activities crystal structures inhibitors novel pockets rho family proteins
	Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文 OAI收割 PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24 作者: Ye, Fei; Huang, Jing; Wang, Hongbo; Luo, Cheng; Zhao, Kehao \| 收藏 \| 浏览/下载：23/0 \| 提交时间：2020/07/01 Epigenetics PRC2 MLL complex SWI/SNF DNMT1 allosteric inhibitors