机构

• 上海药物研究所 [10]
• 上海营养与健康研究所 [2]
• 青岛生物能源与过程研... [1]
• 上海生物化学与细胞生... [1]
• 合肥物质科学研究院 [1]
• 近代物理研究所 [1]
• 更多

采集方式

• OAI收割 [16]

内容类型

• 期刊论文 [16]

发表日期

• 2018 [3]
• 2017 [1]
• 2016 [1]
• 2014 [1]
• 2013 [2]
• 2012 [4]
• 更多

学科主题

• Cell Biolo... [1]
• Chemistry [1]
• Pharmacolo... [1]
• 支撑与管理::仿真与... [1]

筛选

浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 4, 页码: 552-562 作者:  Liu, Feifei;  Yang, Xiaotong;  Geng, Meiyu;  Huang, Min   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 Mitogen-activated protein kinases  Extracellular signal-regulated kinase  ERK inhibitor  ERK kinase  Cancer therapy  Drug resistance   Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387 作者:  Lei, Saifei;  Clydesdale, Lachlan;  Dai, Antao;  Cai, Xiaoqing;  Feng, Yang   |  收藏  |  浏览/下载：63/0  |  提交时间：2019/01/08 G protein-coupled receptor (GPCR)  glucagon  receptor structure-function  cell signaling  site-directed mutagenesis  biased agonism  GLP-1 receptor  glucagon-like peptide-1  class B peptide hormone  ERK kinase  arrestin  transmembrane domain   targetingerkanachillesheelofthemapkpathwayincancertherapy 期刊论文  OAI收割 actapharmaceuticasinicab, 2018, 卷号: 8, 期号: 4, 页码: 552 作者:  Liu Feifei;  Yang Xiaotong;  Geng Meiyu;  Huang Min   |  收藏  |  浏览/下载：71/0  |  提交时间：2020/07/01 Mitogen-activated protein kinases  Extracellular signal-regu lated kinase  ERK inhibitor  ERK kinase  Cancer therapy  Drug resistance   Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K alpha-selective Inhibitors in Breast Cancer 期刊论文  OAI收割 THERANOSTICS, 2017, 卷号: 7, 期号: 4, 页码: 974-986 作者:  Xu, Yi-chao;  Wang, Xiang;  Chen, Yi;  Chen, Si-meng;  Yang, Xin-ying   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BYL719  PI3K  ERK  receptor tyrosine kinase  breast cancer  predictive biomarker   Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 11, 页码: 2600-2604 作者:  Li, Lei;  Liu, Feifei;  Jin, Nan;  Tang, Shuai;  Chen, Zhuxi   |  收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 ERK1/2 kinase inhibitor  Indazole amide  Structure based drug design   Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2) 期刊论文  OAI收割 BIOCHEMICAL JOURNAL, 2014, 卷号: 464, 期号: 2, 页码: 281-289 作者:  Liu, Hao;  Yu, Junjie;  Xia, Tingting;  Xiao, Yuzhong;  Zhang, Qian 收藏  |  浏览/下载：14/0  |  提交时间：2016/01/15 db/db mice  extracellular-signal-regulated kinase 1/2 (ERK 1/2)  glucose  hepatocyte  insulin signalling  liver  serum-and glucocorticoid-regulated kinase 1 (SGK 1)   Modulation of A(2a) receptor antagonist on D-2 receptor internalization and ERK phosphorylation 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1292-1300 作者:  Huang, Li;  Wu, Dong-dong;  Zhang, Lei;  Feng, Lin-yin   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 D-2 receptor  A(2a) receptor  striatum  Parkinson's disease  receptor heterodimerization  receptor internalization  Src kinase  beta-arrestin  ERK  ZM241385   Modulation of A_(2a) receptor antagonist on D_2 receptor internalization and ERK phosphorylation 期刊论文  OAI收割 Acta Pharmacologica Sinica, 2013, 卷号: 34, 期号: 10, 页码: 1292 作者:  Huang Li;  Wu Dongdong;  Zhang Lei;  Feng Linyin   |  收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 PARKINSONS-DISEASE  DOPAMINE-RECEPTORS  BETA-ARRESTIN  G-PROTEIN  ISTRADEFYLLINE KW-6002  ACTIVATION  CELLS  NEURONS  ROLES  TRIAL  D-2 receptor  A(2a) receptor  striatum  Parkinson's disease  receptor heterodimerization  receptor internalization  Src kinase  beta-arrestin  ERK  ZM241385   Computation of relative binding free energy for an inhibitor and its analogs binding with Erk kinase using thermodynamic integration MD simulation 期刊论文  OAI收割 J Comput Aided Mol Des., 2012, 卷号: 26, 期号: 10, 页码: 1159-69 Kuan-Wei Wu; Po-Chin Chen; Jun Wang; Ying-Chieh Sun 收藏  |  浏览/下载：21/0  |  提交时间：2012/11/12 Thermodynamic integration – MD simulation – Relative binding free energy – Erk kinase – Inhibitor   Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721 期刊论文  OAI收割 FOOD AND CHEMICAL TOXICOLOGY, 2012, 卷号: 50, 页码: 1962-1968 作者:  Wang, Li;  Sun, Chao;  Wang, Zhen-Hua;  Guo, Guang-Qin   |  收藏  |  浏览/下载：29/0  |  提交时间：2018/07/05 Ortho-topolin Riboside  Apoptosis  Akt  Erk1/2  Adenosine Kinase  Human Hepatoma Cell