中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
西北高原生物研究所 [6]
上海药物研究所 [4]
高能物理研究所 [4]
物理研究所 [2]
南海海洋研究所 [2]
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期刊论文 [31]
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学位论文 [1]
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2026 [1]
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Impact of electrostatic distribution in CYP3A4 on the regioselectivity of triazolam metabolism and regulation of its metabolic rate by the iron spin states: Insights from MD simulations and QM calculations
期刊论文
OAI收割
JOURNAL OF INORGANIC BIOCHEMISTRY, 2026, 卷号: 276, 页码: 12
作者:
Zhao, Yan
;
Ma, Xinyu
;
Zheng, Qingchuan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2026/01/29
Triazolam
Cytochrome P450 enzyme
Regioselectivity
Metabolic mechanism
MD simulation
QM calculation
Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta
期刊论文
OAI收割
FRONTIERS IN PLANT SCIENCE, 2023, 卷号: 14, 页码: 1074184
作者:
Li,Jinliang
;
Li,Fengchao
;
Wu,Guoxing
;
Gui,Furong
;
Li,Hongmei
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2024/05/09
Laggera pterodonta
sesquiterpenes
acetylcholinesterase
enzyme kinetics
toxic effects
DERIVATIVES
FLAVONOIDS
TERPENOIDS
MECHANISM
Editorial: Pharmacokinetics of herbal medicines and herb-drug interactions
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 3
作者:
Jia, Wei-Wei
;
Lu, Chuang
;
Lin, Ge
;
Ge, Guang-Bo
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2023/04/10
herbal medicine
pharmacokinetics
drug combination
drug interaction
molecular mechanism
drug transporter
drug-metabolizing enzyme
The carbonate concentration mechanism ofPyropia yezoensis(Rhodophyta): evidence from transcriptomics and biochemical data
期刊论文
OAI收割
BMC PLANT BIOLOGY, 2020, 卷号: 20, 期号: 1, 页码: 12
作者:
Zhang, Baoyu
;
Xie, Xiujun
;
Liu, Xuehua
;
He, Linwen
;
Sun, Yuanyuan
  |  
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2021/04/12
Carbon concentrating mechanism
Enzyme activity
Pyropia yezoensis
Photosynthetic efficiency
Transcriptome
Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 14, 页码: 4709, 4722
作者:
Manenda, Mahder S.
;
Picard, Marie-Eve
;
Zhang, Liping
;
Cyr, Normand
;
Zhu, Xiaojun
  |  
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2020/09/22
flavin adenine dinucleotide (FAD)
enzyme catalysis
enzyme mechanism
small-angle X-ray scattering (SAXS)
crystal structure
flavin-dependent monooxygenase
hydroxylation
mobile flavin
piericidin
sliding conformation
Synthetic Catalysts Inspired by Hydrolytic Enzymes
期刊论文
OAI收割
ACS CATALYSIS, 2019, 卷号: 9, 期号: 1, 页码: 168-187
作者:
Nothling, Mitchell D.
;
Xiao, Zeyun
;
Bhaskaran, Ayana
;
Blyth, Mitchell T.
;
Bennet, Christopher W.
  |  
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/03/01
hydrolytic enzyme
enzyme mimic
catalyst
catalytic triad
reaction mechanism
Template-specific fidelity of DNA replication with high-order neighbor effects: A first-passage approach
期刊论文
OAI收割
PHYSICAL REVIEW E, 2019, 卷号: 100, 期号: 1, 页码: 12131
作者:
Li, Qiu-Shi
;
Zheng, Pei-Dong
;
Shu, Yao-Gen
;
Ou-Yang, Zhong-Can
;
Li, Ming
  |  
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2020/06/16
MECHANISM
ENZYME
单核非血红素金属-氧加合物的合成、表征与反应活性研究
学位论文
OAI收割
北京: 中国科学院大学, 2018
作者:
杜俊毅
  |  
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2019/09/12
模拟酶
C-H键活化
环氧化
机理
Enzyme Models
C-H Activation
Epoxidation
Mechanism
The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2016, 卷号: 1864, 期号: 12, 页码: 1641-1648
作者:
Yachnin, Brahm J.
;
Lau, Peter C. K.
;
Berghuis, Albert M.
收藏
  |  
浏览/下载:288/0
  |  
提交时间:2017/03/13
Baeyer-Villiger monooxygenase
Small-angle X-ray scattering (SAXS)
Isothermal titration calorimetry (ITC)
Protein flexibility
Enzyme mechanism
Enzyme catalysis
Mechanism of the allosteric regulation of streptococcus mutans 2 '-deoxycytidylate deaminase
期刊论文
iSwitch采集
Acta crystallographica section d-structural biology, 2016, 卷号: 72, 期号: 7, 页码: 883-891
作者:
Li, Yanhua
;
Guo, Zhen
;
Jin, Li
;
Wang, Deqiang
;
Gao, Zengqiang
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/04/23
Allosteric regulation
Crystal structure
Enzyme inactivation
Enzyme mechanism
Enzyme structure
2 '-deoxycytidylate deaminase
Streptococcus mutans