中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [24]
上海生物化学与细胞生... [4]
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期刊论文 [36]
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2025 [1]
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Bicyclic polyprenylated acylphloroglucinol-related meroterpenoids as potent DRAK2 inhibitors from
Hypericum patulum
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 10
作者:
Huang, Jin-Chang
;
Jia, Xin-Yu
;
Lv, Yi-Fan
;
Xu, Hong-Hong
;
Han, Ming
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Hypericum patulum
Hypericaceae
Meroterpenoids
Hyperpatins A-H
Death-associated protein kinase-related
apoptosis-inducing kinase 2
Glucose-stimulated insulin secretion
Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into 8-position to the carboxylic acid
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115267
作者:
Chen, Cheng
;
Guo, Shi-Meng
;
Sun, Yuanjun
;
Li, He
;
Hu, Nan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/27
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes mellitus
Lipophilicity
Liver safety
Three-in-one pharmacophore
2-(phenylsulfinyl)acetic acid
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
OAI收割
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
Liver-Target and Glucose-Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 15
作者:
Wang, Aohua
;
Fan, Weiwei
;
Yang, Tiantian
;
He, Shufang
;
Yang, Yiwei
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
glucose responsive
insulin secretion
liver target
oral drug delivery
polymersomes
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:
Kong, Deyu
;
Guo, Shimeng
;
Yang, Yushe
;
Guo, Bin
;
Xie, Xin
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
FFA1 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
OAI收割
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
  |  
收藏
  |  
浏览/下载:120/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation
期刊论文
OAI收割
BIOCHEMICAL JOURNAL, 2019, 卷号: 476, 页码: 513-533
作者:
Lu, Jing
;
Willars, Gary B.
;
,
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/21
GLP-1 RECEPTOR
BETA-ARRESTINS
DIFFERENTIAL TRAFFICKING
INSULIN-SECRETION
SUBSTANCE-P
PROTEIN
PHOSPHORYLATION
GLUCOSE
DESENSITIZATION
INTERNALIZATION
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:
Guo, Bin
;
Guo, Shimeng
;
Huang, Jing
;
Li, Jingya
;
Li, Jia
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2019/01/08
GPR40 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia
期刊论文
OAI收割
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 卷号: 45, 期号: 12, 页码: 1257-1264
作者:
Zhou, Tingting
;
Du, Mengfan
;
Zhao, Tong
;
Quan, Lingling
;
Zhu, Zhiyuan
  |  
收藏
  |  
浏览/下载:113/0
  |  
提交时间:2019/01/08
beta cell
apoptosis
glucose-stimulated insulin secretion
T2DM
Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp
期刊论文
OAI收割
JOURNAL OF DIABETES, 2018, 卷号: 10, 期号: 11, 页码: 874-885
作者:
Xie, Xiaoyan
;
Ma, Jing
;
Xu, Min
;
Zhao, Xinjie
;
Gu, Weiqiong
  |  
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/06/20
bile acid
hyperglycemic clamp
insulin secretion
type 2 diabetes mellitus