中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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机构
上海神经科学研究所 [6]
上海药物研究所 [5]
金属研究所 [3]
上海生物化学与细胞生... [2]
昆明植物研究所 [1]
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OAI收割 [17]
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期刊论文 [17]
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2019 [1]
2015 [1]
2014 [2]
2013 [3]
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3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Synthesis and biological evaluation of 3-([1,2,4]triazolo [4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3 beta inhibitors and neuroprotective agents
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 5, 页码: 1179-1188
作者:
Ye, Qing
;
Mao, Weili
;
Zhou, Yubo
;
Xu, Lei
;
Li, Qiu
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
GSK-3 beta inhibitors
Maleimides
Kinase activity
Neuroprotective agents
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
作者:
Lv Wenwen
;
Qin Sining
;
Chen Congqin
;
Zhang Jinjie
;
Ren Tianshu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2021/02/02
ENDOTHELIAL GROWTH-FACTOR
DRUG-INDUCED APOPTOSIS
HEMATOLOGICAL MALIGNANCIES
ACTIN REORGANIZATION
ANTICANCER DRUG
BONE-MARROW
KINASE AKT
CANCER
THALIDOMIDE
MIGRATION
isoindolone
anticancer drug
leukemia
zebrafish
angiogenesis
apoptosis
AKT
GSK3 beta
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
作者:
Lv Wenwen
;
Qin Sining
;
Chen Congqin
;
Zhang Jinjie
;
Ren Tianshu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/02/02
ENDOTHELIAL GROWTH-FACTOR
DRUG-INDUCED APOPTOSIS
HEMATOLOGICAL MALIGNANCIES
ACTIN REORGANIZATION
ANTICANCER DRUG
BONE-MARROW
KINASE AKT
CANCER
THALIDOMIDE
MIGRATION
isoindolone
anticancer drug
leukemia
zebrafish
angiogenesis
apoptosis
AKT
GSK3 beta
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2013, 卷号: 9, 期号: 9, 页码: 579-U82
作者:
Wang, Sheng
;
Yin, Junlin
;
Chen, Duozhi
;
Nie, Fen
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2013/10/16
Glycogen-synthase Kinase-3
Beta-catenin
Negative Regulator
Dix Domain
Stem-cells
In-vivo
Axin
Activation
Pathway
Phosphorylation
Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2013, 卷号: 203, 期号: 1, 页码: 309-313
作者:
Jing, P
;
Zhang, JY
;
Ouyang, Q
;
Wu, J
;
Zhang, XJ
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2015/07/22
Acetylcholinesterase (AChE)
Glycogen synthase kinase-3 beta (GSK3 beta)
HEK293T cells
Proteasome
Design,synthesis and biological evaluation of benzothiazinones as novel non-ATP competitive inhibitors of glycogen synthesis kinase 3beta (GSK-3beta)
期刊论文
OAI收割
Chinese Journal of Medicinal Chemistry, 2013, 卷号: 23, 期号: 6, 页码: 444-452
作者:
Lu Wenbo
;
Zhang Peng
;
Huang Ke
;
Chu Yong
;
Ye Deyong
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
GSK-3beta
synthesis
benzothiazinones
glycogen synthesis kinase 3beta
non-ATP competitive inhibitor
structure-activity relationships
Exposure to Pyrithiamine Increases beta-Amyloid Accumulation, Tau Hyperphosphorylation, and Glycogen Synthase Kinase-3 Activity in the Brain
期刊论文
OAI收割
NEUROTOXICITY RESEARCH, 2011, 卷号: 19, 期号: 4, 页码: 575-583
Zhao, Jing
;
Sun, Xiaojing
;
Yu, Zhe
;
Pan, Xiaoli
;
Gu, Fenghua
;
Chen, Jia
;
Dong, Wenxin
;
Zhao, Lei
;
Zhong, Chunjiu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2012/07/13
Alzheimer's disease
Thiamine deficiency
Pyrithiamine
Glycogen synthase kinase-3
POSITRON-EMISSION-TOMOGRAPHY
FAMILIAL ALZHEIMERS-DISEASE
THIAMINE-DEPENDENT ENZYMES
TRANSGENIC MICE
WERNICKES ENCEPHALOPATHY
INSULIN-RESISTANCE
PRECURSOR PROTEIN
MOUSE MODELS
A-BETA
DEFICIENCY
Implication of Wnt Signaling in Neuronal Polarization
期刊论文
OAI收割
DEVELOPMENTAL NEUROBIOLOGY, 2011, 卷号: 71, 期号: 6, 页码: 495-507
作者:
Luo, Zhen-Ge
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2012/07/13
Wnt
neuronal polarization
axon development
cytoskeleton
ADENOMATOUS POLYPOSIS-COLI
GLYCOGEN-SYNTHASE KINASE-3-BETA
ASYMMETRIC CELL DIVISIONS
C-ELEGANS EMBRYOS
BETA-CATENIN
CAENORHABDITIS-ELEGANS
XENOPUS EMBRYOS
AXON FORMATION
AXIS FORMATION
CORTICAL-NEURONS