中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
大连化学物理研究所 [3]
近代物理研究所 [3]
上海药物研究所 [1]
合肥物质科学研究院 [1]
采集方式
OAI收割 [8]
内容类型
期刊论文 [8]
发表日期
2024 [1]
2020 [4]
2012 [3]
学科主题
物理化学 [2]
筛选
浏览/检索结果:
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An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8
作者:
Li, Huiwen
;
Cai, Xinhui
;
Yang, Xiaoyu
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/09/26
MDM2
PROTAC
p53
MDMX
Targeted protein degradation
MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment
期刊论文
OAI收割
JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 卷号: 12, 期号: 9, 页码: 713-722
作者:
Wang, Bing
;
Lim, Chuan-Bian
;
Yan, Jiawei
;
Li, Lizhen
;
Wang, Jufang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/10
p53
MDMX
tumor microenvironment
immune cell infiltration
macrophage polarization
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yu, De-Hua
;
Xu, Zhi-Yuan
;
Mo, Shaowei
;
Yuan, Li
;
Cheng, Xiang-Dong
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/10/26
MDMX
MDM2
p53
oncogene
tumor suppressor
inhibitors
The MDM2/MDMX/p53 axis in the adaptive stress response
期刊论文
OAI收割
TRANSLATIONAL CANCER RESEARCH, 2020, 卷号: 9, 期号: 3, 页码: 1993-1997
作者:
Wang, Bing
;
Rasmussen-Ivey, Cody
;
Little, John B.
;
Yuan, Zhi-Min
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/18
The MDM2/MDMX/p53 axis
mild stress
adaptive stress response
cell fate
MDMX phosphorylation-dependent p53 down regulation contributes to an immunosuppressive tumor microenvironment
期刊论文
OAI收割
Journal of Molecular Cell Biology, 2020, 卷号: 12, 期号: 9, 页码: 713-722
作者:
Wang Bing
;
Lim Chuanbian
;
Yan Jiawei
;
Li Lizhen
;
Wang Jufang
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/12/10
p53
MDMX
tumor microenvironment
immune cell infiltration
macrophage polarization
Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function
期刊论文
OAI收割
international journal of molecular sciences, 2012, 卷号: 13, 期号: 8, 页码: 9709-9740
作者:
Fu, Ting
;
Min, Hanyi
;
Xu, Yong
;
Chen, Jianzhong
;
Li, Guohui
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2013/10/11
p53
MDM2
MDMX
molecular dynamic simulation
conformational change
protein-protein interaction
protein-ligand interaction
A computational analysis of interaction mechanisms of peptide and non-peptide inhibitors with MDMX based on molecular dynamics simulation
期刊论文
OAI收割
computational and theoretical chemistry, 2012, 卷号: 984, 页码: 43-50
作者:
Cheng, Wei-yuan
;
Chen, Jian-zhong
;
Liang, Zhi-qiang
;
Li, Guo-hui
;
Yi, Chang-hong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2013/10/11
MD simulation
Computational alanine scanning
MM-GBSA method
p53-MDMX interaction
Cross correlation analysis
Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations
期刊论文
OAI收割
international journal of molecular sciences, 2012, 卷号: 13, 期号: 2, 页码: 2176-2195
作者:
Chen, Jianzhong
;
Zhang, Dinglin
;
Zhang, Yuxin
;
Li, Guohui
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2015/11/13
p53-MDM2/MDMX interaction
molecular dynamics simulation
binding free energy
alanine scanning