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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
大连化学物理研究所 [5]
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期刊论文 [59]
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One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 18
作者:
Li, Huaxuan
;
Yang, Hong
;
Liu, Li
;
Zheng, Jiahong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/12/11
Protein arginine methyltransferase 5
Nucleoside derivatives
Piperazine
Metabolic stability
Symmetric dimethylarginines
Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19
作者:
Chen, Yuting
;
Wang, Zekun
;
Zhang, Junjie
;
Shi, Qiongyu
;
Yang, Hong
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/07
PRMT5
Nucleoside derivatives
Methyltransferases
Structure -activity relationship
Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, 卷号: 19, 期号: 3, 页码: 772-788
作者:
Chen, Man-man
;
Guo, Wei
;
Chen, Si-meng
;
Guo, Xiao-zhen
;
Xu, Lan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/03/27
Xanthine dehydrogenase
nucleoside degradation
cell survival
UPR
autophagy
LUAD
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 20
作者:
Chen, Yuting
;
Shi, Qiongyu
;
Yang, Hong
;
Li, Jiayi
;
Zhou, Kaixin
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2023/04/10
Epigenetic
PRMT5 inhibitor
Nucleoside derivatives
Structure-activity Relationship Prodrug
Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2022, 页码: 10
作者:
Yuan, Meng
;
Hu, Wenjuan
;
Feng, Yingying
;
Tong, Yue
;
Wang, Xin
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/06/15
diabetic nephropathy
LC-MS
MS
nucleoside
pharmacokinetics
remdesivir
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 9
作者:
Qian, Hong-jie
;
Wang, Yu
;
Zhang, Meng-qi
;
Xie, Yuan-chao
;
Wu, Qing-qing
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2022/06/15
VV116
nucleoside analog
SARS-CoV-2
safety
pharmacokinetics
healthy subjects
Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
期刊论文
OAI收割
TALANTA, 2022, 卷号: 239, 页码: 8
作者:
Song, Zhihua
;
Song, Yanqin
;
Wang, Yinghao
;
Liu, Jinqiu
;
Wang, Yumeng
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/11/15
Molecularly imprinted polymers (MIPs)
High performance liquid chromatography
Stationary phases
Silica microbeads
Nucleoside analogues
Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
期刊论文
OAI收割
TALANTA, 2022, 卷号: 239, 页码: 8
作者:
Song, Zhihua
;
Song, Yanqin
;
Wang, Yinghao
;
Liu, Jinqiu
;
Wang, Yumeng
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/08/13
Molecularly imprinted polymers (MIPs)
High performance liquid chromatography
Stationary phases
Silica microbeads
Nucleoside analogues
Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides
期刊论文
OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 页码: 12
作者:
Xue, Haitao
;
Guo, Shuang
;
Hu, Tianwen
;
Wei, Daibao
;
Xie, Yuanchao
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2022/01/18
2 '-deoxy carbocyclic nucleoside
antiviral activity
hepatitis B virus
Mitsunobu reaction
Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and beta-d-N-4-hydroxycytidine
期刊论文
OAI收割
VIROLOGICA SINICA, 2021, 页码: 9
作者:
Xie, Yuanchao
;
Guo, Xiaozhen
;
Hu, Tianwen
;
Wei, Daibao
;
Ma, Xiuli
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Porcine epidemic diarrhea virus (PEDV)
Nucleoside analog
RNA dependent RNA polymerase (RdRp)
Antiviral activity