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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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期刊论文 [59]
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One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 18
作者:
Li, Huaxuan
;
Yang, Hong
;
Liu, Li
;
Zheng, Jiahong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/12/11
Protein arginine methyltransferase 5
Nucleoside derivatives
Piperazine
Metabolic stability
Symmetric dimethylarginines
Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19
作者:
Chen, Yuting
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/05/07
PRMT5
Nucleoside derivatives
Methyltransferases
Structure -activity relationship
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 20
作者:
Chen, Yuting
;
Shi, Qiongyu
;
Yang, Hong
;
Li, Jiayi
;
Zhou, Kaixin
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2023/04/10
Epigenetic
PRMT5 inhibitor
Nucleoside derivatives
Structure-activity Relationship Prodrug
Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, 卷号: 19, 期号: 3, 页码: 772-788
作者:
Chen, Man-man
;
Guo, Wei
;
Chen, Si-meng
;
Guo, Xiao-zhen
;
Xu, Lan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/27
Xanthine dehydrogenase
nucleoside degradation
cell survival
UPR
autophagy
LUAD
Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2022, 页码: 10
作者:
Yuan, Meng
;
Hu, Wenjuan
;
Feng, Yingying
;
Tong, Yue
;
Wang, Xin
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/06/15
diabetic nephropathy
LC-MS
MS
nucleoside
pharmacokinetics
remdesivir
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 9
作者:
Qian, Hong-jie
;
Wang, Yu
;
Zhang, Meng-qi
;
Xie, Yuan-chao
;
Wu, Qing-qing
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2022/06/15
VV116
nucleoside analog
SARS-CoV-2
safety
pharmacokinetics
healthy subjects
Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
期刊论文
OAI收割
TALANTA, 2022, 卷号: 239, 页码: 8
作者:
Song, Zhihua
;
Song, Yanqin
;
Wang, Yinghao
;
Liu, Jinqiu
;
Wang, Yumeng
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/13
Molecularly imprinted polymers (MIPs)
High performance liquid chromatography
Stationary phases
Silica microbeads
Nucleoside analogues
Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
期刊论文
OAI收割
TALANTA, 2022, 卷号: 239, 页码: 8
作者:
Song, Zhihua
;
Song, Yanqin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/11/15
Molecularly imprinted polymers (MIPs)
High performance liquid chromatography
Stationary phases
Silica microbeads
Nucleoside analogues
Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides
期刊论文
OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 页码: 12
作者:
Xue, Haitao
;
Guo, Shuang
;
Hu, Tianwen
;
Wei, Daibao
;
Xie, Yuanchao
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2022/01/18
2 '-deoxy carbocyclic nucleoside
antiviral activity
hepatitis B virus
Mitsunobu reaction
Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and beta-d-N-4-hydroxycytidine
期刊论文
OAI收割
VIROLOGICA SINICA, 2021, 页码: 9
作者:
Xie, Yuanchao
;
Guo, Xiaozhen
;
Hu, Tianwen
;
Wei, Daibao
;
Ma, Xiuli
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/05/24
Porcine epidemic diarrhea virus (PEDV)
Nucleoside analog
RNA dependent RNA polymerase (RdRp)
Antiviral activity