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浏览/检索结果: 共239条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53 期刊论文  OAI收割 出版物, 3111, 期号: 0, 页码: 1-37 作者:  Baihe Chen;  Di Lu;  Yujuan Fu;  Jingwen Zhang;  Xiaobo Huang   |  收藏  |  浏览/下载：318/0  |  提交时间：2017/07/24 Cardiac Rupture  Olmesartan  P53  Gdf-15  Aldosterone  Myocardial Infarction   Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo 期刊论文  OAI收割 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2026, 卷号: 74, 期号: 6, 页码: 5237-5255 作者:  Hu, Bintao;  Li, Han;  Tang, Chunping;  Ke, Chang-Qiang;  Ding, Jian   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/04/01 withanolide  Physalis angulata  antimelanoma  p53 signaling pathway   Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 297, 页码: 20 作者:  Wang, Zhiyi;  Zhang, Shijie;  Irakoze, Loica Melita;  Zhao, Yujun   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/12/04 p53  MDM2  Protein-protein interaction  Mutant p53  Gene therapy  PROTAC  Degrader   A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/ Caspase 3 signaling pathway 期刊论文  OAI收割 JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 351, 页码: 12 作者:  Zhou, Yue;  Zhang, Baowen;  Wang, Xiaodan;  Liu, Xiaoqin;  Zhao, Jinna   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 Acute kidney injury  Ganoderma lucidum (leyss. ex Fr.) Karst spore  Molecular docking  p53   Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9 作者:  Li, Linquan;  Gu, Xi;  Meng, Jingyi;  Wen, Yiming;  Yi, Jing   |  收藏  |  浏览/下载：26/0  |  提交时间：2025/05/27 p53 Y220C  Synthesis  Structural modification  Drug design   Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：59/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention 期刊论文  OAI收割 JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2024, 页码: 15 作者:  Zou, Zi-Yuan;  Ren, Tian-Yi;  Jiao, Ting-Ying;  Wang, Meng-Yu;  Huang, Lei-Jie   |  收藏  |  浏览/下载：54/0  |  提交时间：2024/09/26 Apoptosis  DNA Damage  Metabolic dysfunction-associated stea- totic liver disease  RNA-Seq  Tumor suppressor protein P53  Western Diets   An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8 作者:  Li, Huiwen;  Cai, Xinhui;  Yang, Xiaoyu;  Zhang, Xuan   |  收藏  |  浏览/下载：46/0  |  提交时间：2024/09/26 MDM2  PROTAC  p53  MDMX  Targeted protein degradation   Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16 作者:  Lin, Zhitong;  Liu, Chen;  Yan, Ziqin;  Cheng, Jing;  Wang, Xiancheng   |  收藏  |  浏览/下载：56/0  |  提交时间：2024/06/27 MDM2  p53  p21  Imidazolidinone  Apoptosis   LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells 期刊论文  OAI收割 MOLECULAR ONCOLOGY, 2023, 卷号: 17, 期号: 8, 页码: 1678-1691 作者:  Xu, Beihui;  Li, Qi;  Zhang, Jianjun;  Chen, Fuxiang   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/27 Ajuba  apoptosis  chemoresistance  colorectal cancer  p53