中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [46]
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期刊论文 [214]
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Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-37
作者:
Baihe Chen
;
Di Lu
;
Yujuan Fu
;
Jingwen Zhang
;
Xiaobo Huang
  |  
收藏
  |  
浏览/下载:262/0
  |  
提交时间:2017/07/24
Cardiac Rupture
Olmesartan
P53
Gdf-15
Aldosterone
Myocardial Infarction
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention
期刊论文
OAI收割
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2024, 页码: 15
作者:
Zou, Zi-Yuan
;
Ren, Tian-Yi
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收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/09/26
Apoptosis
DNA Damage
Metabolic dysfunction-associated stea- totic liver disease
RNA-Seq
Tumor suppressor protein P53
Western Diets
An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8
作者:
Li, Huiwen
;
Cai, Xinhui
;
Yang, Xiaoyu
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/09/26
MDM2
PROTAC
p53
MDMX
Targeted protein degradation
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16
作者:
Lin, Zhitong
;
Liu, Chen
;
Yan, Ziqin
;
Cheng, Jing
;
Wang, Xiancheng
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/06/27
MDM2
p53
p21
Imidazolidinone
Apoptosis
LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells
期刊论文
OAI收割
MOLECULAR ONCOLOGY, 2023, 卷号: 17, 期号: 8, 页码: 1678-1691
作者:
Xu, Beihui
;
Li, Qi
;
Zhang, Jianjun
;
Chen, Fuxiang
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收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/27
Ajuba
apoptosis
chemoresistance
colorectal cancer
p53
A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate
期刊论文
OAI收割
ARCHIVES OF TOXICOLOGY, 2022, 卷号: 96, 期号: 9, 页码: 2545-2557
作者:
Ji, Di
;
Yu, Yuejin
;
Zhu, Qicheng
;
Li, Xianjie
;
Zhong, Xiali
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收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/11/08
ORGANOPHOSPHORUS FLAME RETARDANTS
PLASTICIZERS
METABOLISM
TOXICITY
CHILDREN
ESTERS
DUST
P53
Discovery of a Potent and Selective Degrader for USP7
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395
作者:
Pei, Yuan
;
Fu, Jingfeng
;
Shi, Yunkai
;
Zhang, Mengmeng
;
Luo, Guanghao
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收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/21
Apoptotic Pathway
Mutant p53
p53 Mutant Cancer Cells
PROTAC
USP7 Degrader
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1
期刊论文
OAI收割
ONCOGENE, 2022, 卷号: 41, 期号: 33, 页码: 4018-4027
作者:
Gao, Ming
;
Qi, Zijuan
;
Deng, Min
;
Huang, Hongyang
;
Xu, Zhijie
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/11/08
HEME OXYGENASE-1
ARSENIC TOXICITY
UBIQUITINATION
USP7/HAUSP
ACTIVATION
MECHANISMS
CANCER
NRF2
P53
Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling
期刊论文
OAI收割
CHEMOSPHERE, 2022, 卷号: 301, 页码: 9
作者:
Wang, Xiaoqing
;
Teng, Yuefa
;
Ji, Chenglong
;
Wu, Huifeng
;
Li, Fei
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/07/26
Metal ions
p53
QSAR
Genetic toxicity
Human health risk