中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [13]
化学研究所 [2]
上海生物化学与细胞生... [2]
生态环境研究中心 [2]
长春应用化学研究所 [2]
近代物理研究所 [2]
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OAI收割 [29]
内容类型
期刊论文 [28]
学位论文 [1]
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2025 [1]
2021 [1]
2018 [4]
2017 [1]
2015 [2]
2014 [5]
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Biochemist... [1]
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Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study
期刊论文
OAI收割
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2025, 卷号: 131, 页码: 11
作者:
Hou, Yingying
;
Miao, Jie
;
Sun, Yajun
;
Shi, Lili
;
Lu, Ouyang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
ADC
LBA
Validation
GLP
PK
CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell
期刊论文
OAI收割
ONCOGENESIS, 2021, 卷号: 10, 期号: 7, 页码: 49
作者:
He,YingYing
;
He,Zhicheng
;
Lin,Jian
;
Chen,Cheng
;
Chen,Yuanzhi
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2022/04/02
BINDING-PROTEIN CTBP
TRANSCRIPTIONAL COREPRESSOR
NEGATIVE MODULATION
PROMOTES APOPTOSIS
GENE-EXPRESSION
DAMAGE RESPONSE
PK
OVEREXPRESSION
PHOSPHOPROTEIN
TRANSFORMATION
细胞的命运: 间充质干细胞的药代动力学
期刊论文
OAI收割
中国细胞生物学学报, 2018, 页码: 10
作者:
韩立
;
惠利健
;
潘国宇
  |  
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2019/01/08
间充质干细胞
药代动力学
PK/PD/TD
Determination of pK (a)and the corresponding structures of quinclorac using combined experimental and theoretical approaches
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2018, 卷号: 1152, 页码: 53-60
作者:
Liu, Huijuan
;
Song, Dean
;
Sun, Huiqing
;
Jiang, Xiaohua
;
Kong, Fanyu
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/06/24
Quinclorac
pK(a)
Spectrophotometric method
Quantitative structure property relationship method
DFT geometry optimization
The Fate of Cells:Pharmacokinetics of MSC
期刊论文
OAI收割
Chinese Journal of Cell Biology, 2018, 卷号: 40, 期号: 6, 页码: 857-866
作者:
Han Li
;
Hui Lijian
;
Pan Guoyu
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
PK/PD/TD
MSC
pharmacokinetics
PK/PD/TD
细胞的命运:间充质干细胞的药代动力学
期刊论文
OAI收割
中国细胞生物学学报, 2018, 卷号: 040, 期号: 006, 页码: 857
作者:
韩立
;
惠利健
;
潘国宇
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
间充质干细胞
药代动力学
PK/PD/TD
Simultaneous determination of the lipophilicity and dissociation constants of dialkyl phosphinic acids by negligible depletion hollow fiber membrane-protected liquid-phase microextraction
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2017, 卷号: 1507, 期号: 0, 页码: 11-17
作者:
Shi, Fengqiong
;
Liu, Jingfu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2018/07/26
Dialkyl Phosphinic Acids (Dpas)
Lipophilicity (Log d)
Dissociation Constant (Pk(a))
Hollow Fiber
Uplc-ms/ms
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12, 页码: 1528-1536
作者:
Gao, Zhi-wei
;
Zhu, Yun-ting
;
Yu, Ming-ming
;
Zan, Bin
;
Liu, Jia
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
OAI收割
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 卷号: 88, 页码: 22-26
作者:
Wang, Jian-Ling
;
Xu, Xue-Jiao
;
Chen, Dong-Ying
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Capillary electrophoresis
External pressure
pK(a)
Triptolide derivative
Impurities
Potentiometric titration