机构

• 上海药物研究所 [6]
• 化学研究所 [1]
• 水生生物研究所 [1]
• 昆明植物研究所 [1]
• 植物研究所 [1]
• 近代物理研究所 [1]
• 更多

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [10]
• 会议论文 [1]

发表日期

• 2021 [2]
• 2019 [2]
• 2018 [1]
• 2015 [1]
• 2013 [2]
• 2011 [1]
• 更多

学科主题

• Plant Scie... [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery 期刊论文  OAI收割 AUTOPHAGY, 2021, 卷号: 17, 期号: 10, 页码: 2905-2922 作者:  Tang, Ying;  Liu, Jinchang;  Wang, Yu;  Yang, Li;  Han, Bing   |  收藏  |  浏览/下载：55/0  |  提交时间：2022/01/04 Autophagy  functional recovery  ischemic stroke  lysophosphatidic acid receptor 5  microglial activation  poly (ADP-ribose) polymerase 14   Poly ADP-ribose polymerase-1 promotes seed-setting rate by facilitating gametophyte development and meiosis in rice (Oryza sativa L.) 期刊论文  OAI收割 PLANT JOURNAL, 2021, 卷号: 107, 期号: 3, 页码: 760-774 作者:  Li, Xiumei;  Zhang, Yixin;  Liu, Qinjian;  Song, Songquan;  Liu, Jun   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/02/24 poly(ADP-ribose) polymerases  seed-setting rate  gametophyte development  meiosis  PARP activity  DNA damage   Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 714-727 作者:  Chen, Hua-Dong;  Chen, Chuan-Huizi;  Wang, Yu-Ting;  Guo, Ne;  Tian, Yu-Nan   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/21 PARP1 inhibitor  PARP1-DNA binding  PARP1-DNA trapping  poly(ADP-ribose) polymerase activity  cytotoxicity   Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials 期刊论文  OAI收割 CANCER SCIENCE, 2019, 卷号: 110, 期号: 3, 页码: 1064-1075 作者:  Wang, Lei;  Yang, Changyong;  Xie, Chengying;  Jiang, Jiahua;  Gao, Mingzhao   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 antitumor activity  fluzoparib  pharmacokinetics  poly(ADP-ribose) polymerase  toxicity   Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression 期刊论文  OAI收割 CANCER SCIENCE, 2018, 卷号: 109, 期号: 3, 页码: 821-831 作者:  Wang, Yu-Ting;  Yuan, Bo;  Chen, Hua-Dong;  Xu, Lin;  Tian, Yu-Nan   |  收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08 53BP1  acquired resistance  phosphatase and tensin homolog deficiency  poly(ADP-ribose) polymerase inhibitors  SAMHD1   靶向聚腺苷二磷酸核糖聚合酶(Poly(ADP-ribose)polymerase,PARP)抑制剂研究 会议论文  OAI收割 作者:  张翱;  缪泽鸿;  丁健   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 聚腺苷二磷酸核糖聚合酶  Poly  ADP-ribose)polymerase,PARP  抑制剂  浮选药剂  PARP   Identification of a Novel Gig2 Gene Family Specific to Non-Amniote Vertebrates 期刊论文  OAI收割 PLOS ONE, 2013, 卷号: 8, 期号: 4, 页码: e60588 作者:  Zhang, Yi-Bing;  Liu, Ting-Kai;  Jiang, Jun;  Shi, Jun;  Liu, Ying 收藏  |  浏览/下载：29/0  |  提交时间：2014/01/06 DEPENDENT PROTEIN-KINASE  ATLANTIC SALMON  GENOME DUPLICATION  ANTIVIRAL RESPONSE  TELEOST FISH  CELL-LINE  EVOLUTION  RNA  VIRUS  POLY(ADP-RIBOSE)   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：44/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   The Key Residues of Active Sites on the Catalytic Fragment for Paclitaxel Interacting with Poly (ADP-Ribose) Polymerase 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2011, 卷号: 28, 期号: 6, 页码: 881-893 作者:  Wang, Yue;  Bian, Fuyong;  Deng, Shengrong;  Shi, Qiang;  Ge, Maofa   |  收藏  |  浏览/下载：17/0  |  提交时间：2019/04/09 Binding Pocket  Active Site  Paclitaxel  Poly(Adp-ribose) Polymerase  Md Simulation  Dft   Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 9, 页码: 1172-1180 作者:  He, Jin-xue;  Yang, Chun-hao;  Miao, Ze-hong   |  收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 poly(ADP-ribose) polymerase inhibitor  DNA repair  BRCA1/2  anticancer agents  homologous recombination