中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [11]
中国科学院大学 [1]
植物研究所 [1]
采集方式
OAI收割 [12]
iSwitch采集 [1]
内容类型
期刊论文 [13]
发表日期
2019 [4]
2018 [2]
2017 [3]
2016 [2]
2014 [2]
学科主题
Evolutiona... [1]
Plant Scie... [1]
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Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
OAI收割
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:
Zhang, Kai-li
;
Shen, Qian-qian
;
Fang, Yan-fen
;
Sun, Yi-ming
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/07/01
PRC2
EZH2-EED
AZD9291
miR-34a
non-canonical base pairing
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:
Shi, Yi
;
Ma, Hong-lei
;
Zhuang, You-wen
;
Wang, Xiao-xi
;
Jiang, Yi
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
c10orf12modulatesprc2histonemethyltransferaseactivityandh3k27me3levels
期刊论文
OAI收割
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1457
作者:
Shi Yi
;
Ma Honglei
;
Zhuang Youwen
;
Wang Xiaoxi
;
Jiang Yi
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
REPRESSIVE COMPLEX 2
GENOMIC TARGETS
POLYCOMB
PROTEIN
CHROMATIN
RECRUITMENT
JARID2
DIFFERENTIATION
BINDING
METHYLATION
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 302-310
作者:
Zhu, Mao-rong
;
Du, Dao-hai
;
Hu, Jun-chi
;
Li, Lian-chun
;
Liu, Jing-qiu
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors
期刊论文
OAI收割
actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 302
作者:
Zhu Maorong
;
Du Daohai
;
Hu Junchi
;
Li Lianchun
;
Liu Jingqiu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
Structure of the PRC2 complex and application to drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 963-976
作者:
Shi, Yi
;
Wang, Xiao-xi
;
Zhuang, You-wen
;
Jiang, Yi
;
Melcher, Karsten
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
PRC2
histone methyltransferase
H3K27me3
nucleosome
structure
drug discovery
structureoftheprc2complexandapplicationtodrugdiscovery
期刊论文
OAI收割
actapharmacologicasinica, 2017, 卷号: 38, 期号: 7, 页码: 963
作者:
Shi Yi
;
Wang Xiaoxi
;
Zhuang Youwen
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
PRC2
histone methyltransferase
H3K27me3
nucleosome
structure
drug discovery
BASIC PENTACYSTEINE Proteins Repress ABSCISIC ACID INSENSITIVE4 Expression via Direct Recruitment of the Polycomb-Repressive Complex 2 in Arabidopsis Root Development
期刊论文
OAI收割
PLANT AND CELL PHYSIOLOGY, 2017, 卷号: 58, 期号: 3, 页码: 607-621
作者:
Mu, Ying
;
Zou, Meijuan
;
Sun, Xuwu
;
He, Baoye
;
Xu, Xiumei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/03/28
ABI4
Arabidopsis
BPC
LR development
PRC2
Identification of novel ezh2 inhibitors through pharmacophore-based virtual screening and biological assays
期刊论文
iSwitch采集
Bioorganic & medicinal chemistry letters, 2016, 卷号: 26, 期号: 15, 页码: 3813-3817
作者:
Wu, Yunlong
;
Hu, Junchi
;
Ding, Hong
;
Chen, Limin
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/05/09
Ezh2
Epigenetics
Prc2
Computational drug design
Pharmacophore-based virtual screening