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	Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation 期刊论文 OAI收割 VIRUSES-BASEL, 2024, 卷号: 16, 期号: 4, 页码: 9 作者: Chen, Yamin; Zha, Jialu; Xu, Shiqi; Shao, Jiang; Liu, Xiaoshan \| 收藏 \| 浏览/下载：15/0 \| 提交时间：2024/05/31 COVID-19 neutralizing antibody structure-based antibody optimization L452R mutation
	The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 149, 页码: 148-169 作者: Peng, Dian; Cao, Bin; Zhou, Ying-Jun; Long, Ya-Qiu \| 收藏 \| 浏览/下载：49/0 \| 提交时间：2019/01/08 CXC chemokine receptor 4 Small molecule antagonists Structure-based optimization HIV-1 entry Tumor metastasis Inflammation Ischemia-reperfusion Autoimmune
	A novel passive micromixer with modified asymmetric lateral wall structures 期刊论文 OAI收割 Asia-Pacific Journal of Chemical Engineering, 2018, 卷号: 13, 期号: 3, 页码: 11 作者: Wang, H. L.; Shi, L. Y.; Zhou, T.; Xu, C.; Deng, Y. B. \| 收藏 \| 浏览/下载：19/0 \| 提交时间：2019/09/17 lateral structure microfluidics numerical simulations passive micromixer secondary flow cfd-based optimization recombination micromixer microfluidic chip design membranes stirrer mixers Engineering
	Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 11, 页码: 1516 作者: Wu Xishan; Wang Rui; Xing Yanli; Xue Xiaoqian; Zhang Yan \| 收藏 \| 浏览/下载：96/0 \| 提交时间：2020/12/24 GAMMA-T ORPHAN RECEPTORS CELL-DIFFERENTIATION LIGAND IDENTIFICATION MODULATORS DERIVATIVES PROTEIN INHIBITORS DOCKING nuclear receptor RORc inverse agonist SAR structure-based optimization autoimmune disease
	Lightweight design of large scale theodolite's turntable based on topology optimization of continuum structure (EI CONFERENCE) 会议论文 OAI收割 2012 International Conference on Optoelectronics and Microelectronics, ICOM 2012, August 23, 2012 - August 25, 2012, Changchun, China 作者: Wang Y.; Wang Y.; Wang Y.; Wang Y.; Wang Y. 收藏 \| 浏览/下载：28/0 \| 提交时间：2013/03/25 In order to solve the problem that the weight of large scale theodolite's casting or steel plate welded structure is too heavy lightweight design of large scale turntable based on topology optimization of continuum structure is investigated. Topology optimization could have better optimization efficiency because it can provide the optimized distribution of material and gain optimized structure in conceptual design phase of the structural design. In order to obtain lightweight and high stiffness structure a truss turntable based on topology optimization of continuum structure is presented and the validity of this lightweight structure is examined by finite element analysis. Comparing to the traditional welding steel turntable the lightweight turntable without changing the static displacement can lose 386.48 kg(lightweight ratio is 26.7%) and its first-order natural frequency raises from 167.02Hz to 173.71Hz. Meanwhile in other aspects this turntable also has better performance than traditional structure. 2012 IEEE.
	Study on ultra-light secondary baffle for coaxial two-mirror telescope (EI CONFERENCE) 会议论文 OAI收割 2012 9th IEEE International Conference on Mechatronics and Automation, ICMA 2012, August 5, 2012 - August 8, 2012, Chengdu, China 作者: Zhang L.; Zhang L. 收藏 \| 浏览/下载：62/0 \| 提交时间：2013/03/25 The coaxial two-mirror telescope consists of two mirrors facing each other. Classical two-mirror arrangements are Gregorian and Cassegrain. These systems are usually applied to space telescopes and often have optical baffles to prevent stray light from entering the focal plane. The optical baffles consist of concentric rings suspended between the secondary and the primary mirror. The secondary baffle for a large two-mirror optical system is designed and analyzed in this paper. According to mission of a telescope the structure should have high stiffness and high reliability and light weight. Compared with invar aluminum alloy and titanium alloy carbon fiber composite is currently the best material in terms of weight-to-strength ratio. It also has advantages of high temperature tolerance and low thermal expansion. So carbon fiber composite is chosen as material to meet requirements of the coaxial telescope. In this paper optimization method based on finite element analysis (FEA) is used for design the secondary baffle. Minimum weight of the baffle is chosen as an objective function. Thicknesses of former tube and vanes are chosen as variables. Analysis results show that the designed secondary baffle has maximum diameter of 180mm total length of 120mm and weighs 142g. And its fundamental frequency reaches 651Hz. Therefore the baffle has many advantages such as ultra-light weight high stiffness and dimensional stability etc. The optimization method and the baffle design can be helpful to other coaxial telescopes such as Cassegrain Gregorian and their subdivisions. 2012 IEEE.
	Optimum design of the carbon fiber thin-walled baffle for the space-based camera (EI CONFERENCE) 会议论文 OAI收割 International Symposium on Photoelectronic Detection and Imaging 2011: Space Exploration Technologies and Applications, May 24, 2011 - May 26, 2011, Beijing, China Yan Y.; Gu S.; An Y.; Jin G. 收藏 \| 浏览/下载：14/0 \| 提交时间：2013/03/25 The thin-walled baffle design of the space-based camera is an important job in the lightweight space camera research task for its stringent quality requirement and harsh mechanical environment especially for the thin-walled baffle of the carbon fiber design. In the paper an especially thin-walled baffle of the carbon fiber design process was described and it is sound significant during the other thin-walled baffle design of the space camera. The designer obtained the design margin of the thin-walled baffle that structural stiffness and strength can tolerated belong to its development requirements through the appropriate use of the finite element analysis of the walled parameters influence sensitivity to its structural stiffness and strength. And the designer can determine the better optimization criterion of thin-walled baffle during the geometric parameter optimization process in such guiding principle. It sounds significant during the optimum design of the thin-walled baffle of the space camera. For structural stiffness and strength of the carbon fibers structure which can been designed the effect of the optimization will be more remarkable though the optional design of the parameters chose. Combination of manufacture process and design requirements the paper completed the thin-walled baffle structure scheme selection and optimized the specific carbon fiber fabrication technology though the FEM optimization and the processing cost and process cycle are retrenchment/saved effectively in the method. Meanwhile the weight of the thin-walled baffle reduced significantly in meet the design requirements under the premise of the structure. The engineering prediction had been adopted and the related result shows that the thin-walled baffle satisfied the space-based camera engineering practical needs very well its quality reduced about 20% the final assessment index of the thin-walled baffle were superior to the overall design requirements significantly. The design method is reasonable and efficient to the other thin-walled baffle that mass and work environment requirement is requirement harsh. 2011 SPIE.
	Optimal design of strap-down inertial navigation support under random loads (EI CONFERENCE) 会议论文 OAI收割 2010 IEEE International Conference on Information and Automation, ICIA 2010, June 20, 2010 - June 23, 2010, Harbin, Heilongjiang, China 作者: Li M. 收藏 \| 浏览/下载：29/0 \| 提交时间：2013/03/25 In order to realize miniaturization and light weight of the strap-down inertial navigation system and then to make sure that it works well under random loads optimal design is applied to the strap-down inertial navigation support with the methods of topology optimization and size optimization. Firstly based on the installation requirement of devices and connection requirement of the support and the carrier the initial structure of the support is designed. Topology optimization with FEA software ANSYS is adopted on the initial structure to get the basic one. Then 5 critical sizes are chosen as design variables and the support structure is optimized by means of size optimization to reach light weight with satisfying the requirement of dynamic stiffness. Finally random vibration analysis is applied to the initial structure. In the mean time random vibration test is carried out to qualify the analysis method. After the qualification a random vibration analysis is applied to the optimized support structure to get the rms of displacement response and acceleration response of the support to validate whether the optimized structure is appropriate. The results indicate that the dynamic stiffness of the optimized support structure satisfies the design requirements and its weight is lighter 49.38% than that of the initial one. This research can be a reference to the structure design of supports under random loads and the result has been applied to the development and manufacture of a prototype aerocraft. 2010 IEEE.
	Research on long focal length On-axis TMA system for high-resolution remote sensing (EI CONFERENCE) 会议论文 OAI收割 3rd International Symposium on Advanced Optical Manufacturing and Testing Technologies, AOMATT 2007: Advanced Optical Manufacturing Technologies, July 8, 2007 - July 12, 2007, Chengdu, China 作者: Zhang L.; Zhang L. 收藏 \| 浏览/下载：25/0 \| 提交时间：2013/03/25 TMA (Three Mirror Anastigmatic) is popular to the design of space-based optical system. This paper describes the characteristics of the on-axis TMA optical system. An on-axis TMA system with 13m focal length is designed and analyzed. To solve the initial configuration parameters Cassagrain structure is confirmed firstly and then the tertiary mirror. Based on initial configuration parameters automatic optimization is executed in ZEMAX program and design result with excellent image quality is acquired which shows the procedure we choosed with good advantage of computer processing. As the distortion of the design reaches 1% its influences on TDICCD brushing camera are discussed. The source of distortion is analyzed and correcting methods are considered. Zero focal power corrector is chosen to correct the distortion and the corrected distortion is less than 0.02%. The research on on-axis TMA system in this paper makes a foundation for farther high-resolution remote sensing applications.