中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [184]
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Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of
Tripterygium
wilfordii
(Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 19
作者:
Cao, Guangchao
;
Ning, Ruonan
;
Zhao, Jie
;
Yao, Jiaying
;
Chang, Linyue
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
Tripterygium wilfordii
Dihydro
beta -agarofuran sesquiterpenoid
Osteoclastgenesis
Immunosuppressive
Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Crassostrea gigas)
期刊论文
OAI收割
MARINE LIFE SCIENCE & TECHNOLOGY, 2023, 页码: 11
作者:
Xu, Fei
;
Deng, Shaoxi
;
Gavriouchkina, Daria
;
Zhang, Guofan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/04/07
Gene regulation network
Indirect development
Lophotrochozoa
Nuclear receptors
Neurohormones
Protein synthesis
Transcription factors
Development of a novel
18
F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 页码: 13
作者:
Bu, Lihong
;
Ma, Xiaowei
;
Ji, Aiyan
;
Geng, Kaijun
;
Feng, Hongyan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/19
Mesenchymal epithelial transition receptor
Gliomas
[18F]-AZC
PET
Quinoline derivative compound
TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage
期刊论文
OAI收割
CANCER MEDICINE, 2023, 页码: 14
作者:
Chang, Shuaikang
;
Xiao, Wenqin
;
Xie, Yongsheng
;
Xu, Zhijian
;
Li, Bo
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
DNA damage
DSBs repair
myeloma
TI17
Trip13
Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 10
作者:
Li, Peizhuo
;
Tian, Yucheng
;
Shang, Qinghong
;
Tang, Cailing
;
Hou, Zeng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
NPAS3
Covalent inhibitor
Protein -protein interaction
5-nitrothiazole warhead
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARa nucleus-cytoplasm shuttling
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18
作者:
Zhong, Jing
;
He, Xiaofang
;
Gao, Xinxin
;
Liu, Qiaohong
;
Zhao, Yu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/08
Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213
作者:
Sun, Nannan
;
Yu, Mingcheng
;
Jiang, Zhengyuan
;
Yang, Feng
;
Lu, Lixue
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
ROR?t agonists
Carbazole carboxamide
Agonistic activity
Metabolic stability
Co-crystallization
Molecular docking
Advances in Medicinal Chemistry of Estrogen-related Receptor Alpha (ERRa) Inverse Agonists
期刊论文
OAI收割
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 20, 页码: 1952-1963
作者:
Zhang, Haibin
;
Du, Yongli
;
Zheng, Yong
;
Lv, Huiting
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/10/17
ERRalpha
ERRalpha inverse agonists
Breast cancer
TNBC
Signaling pathways
Inverse agonistic activity
Potential adverse outcome pathways with hazard identification of organophosphate esters
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 卷号: 851, 页码: 13
作者:
Wang, Xiaoqing
;
Li, Fei
;
Teng, Yuefa
;
Ji, Chenglong
;
Wu, Huifeng
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/01/11
Organophosphate esters (OPEs)
Network-centric analysis
Risk assessment
Adverse outcome pathway
Quantitative weight of evidence
Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1
期刊论文
OAI收割
CNS NEUROSCIENCE & THERAPEUTICS, 2022, 页码: 14
作者:
Su, Jian-Wei
;
Yang, Pei
;
Xing, Mei-Mei
;
Chen, Bao
;
Xie, Xia-Hong
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
C
elegans
corals-derived compounds
neuroprotection
Nurr1
SH-SY5Y cells