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浏览/检索结果: 共139条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2025, 卷号: 237, 页码: 12 作者:  Yan, Shiyu;  Chen, Yan;  Wang, Jiang;  Wang, Qiuying;  Zhou, Qingtong   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 RXFP4  INSL5  Agonist  Constipation  Colonic motility   Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 15 作者:  Tang, Siyuan;  Hu, Shuyang;  Feng, Lijing;  Kong, Linghui;  Gui, Jiangwen   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/05/27 N-Cyclopropylmethyl-nornepenthones  Structure-activity relationship  MOR antagonist  KOR agonist  Substance use disorder   Drug discovery targeting thyroid hormone receptor f3 (THRf3) for the treatment of liver diseases and other medical indications 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 35-51 作者:  Wang, Kean;  Chen, Feiyang;  Wang, Jiang;  Liu, Hong   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/04/01 Thyroid hormone  Thyroid hormone /3 receptor  MASLD  MASH  THR/3 agonist   Discovery of a non-nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect 期刊论文  OAI收割 MEDCOMM, 2025, 卷号: 6, 期号: 1, 页码: e70001 作者:  Wang, Xiyuan;  Zhan, Zhengsheng;  Wang, Zhen;  Zhang, Yan;  Zhao, Kaiyan   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/04 antitumor  immune memory  innate immunity  STING agonist   Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 278, 页码: 15 作者:  Ding, Dong;  Gao, Runing;  Lei, Yujuan;  Liu, Jianing;  Zhou, Chengkai   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/10/21 TLR4 agonist  NOD2 agonist  Adjuvant  Covalent conjugation  Subunit vaccine   The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia 期刊论文  OAI收割 PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 242, 页码: 13 作者:  Cheng, Jiaxin;  Wu, Chunhui;  Wang, Yu;  Wang, Zhen;  He, Yang   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/09/24 TPN672MA  5-HT 1A receptor agonist  D 2 /D 3 receptor partial agonist  5-HT 2A receptor antagonist  Antidepressant-like  Mechanism   FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15 作者:  Wen, Ying-quan;  Zou, Zi-yuan;  Zhao, Guan-guan;  Zhang, Meng-jiao;  Zhang, Yong-xin   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/08/22 MASLD/MASH  FXR  transcriptome  gut-liver axis  agonist   Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26, 页码: 10 作者:  Li, Jingru;  You, Chongzhao;  Li, Yang;  Li, Changyao;  Fan, Wenjia   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/08/22 SSTR5  peptide agonists  agonist selectivity  receptor activation   A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19 作者:  Wang, Xiaoyan;  Yun, Ying;  Chen, Lili;  Guo, Shimeng;  Niu, Buying   |  收藏  |  浏览/下载：36/0  |  提交时间：2024/07/12 Diabetes  GLP-1 receptor  Agonist  Structural optimization  Water molecule replacement  Structure activity relationship  Docking simulation   Design, Synthesis and Bioactivity of NYX-2925 L-Proline Derivatives as N-Methyl-D-aspartate (NMDA) Receptor Partial Agonists 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 4, 页码: 1247-1263 作者:  Wu Youjin;  Jin Zhengsheng;  Liu Yongjia;  Huang Wenqian;  Zhao Guilong   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/08/22 N-methyl-D-aspartate (NMDA) receptor  partial agonist  NYX-2925  synthesis  bioactivity