中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [46]
生态环境研究中心 [5]
昆明植物研究所 [4]
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期刊论文 [65]
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Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists
期刊论文
OAI收割
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2026, 卷号: 48, 期号: 1, 页码: 15
作者:
Tang, Manqing
;
Guo, Qiuhui
;
Wang, Ping
;
Li, Yunfei
;
Jiang, Bo
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/06/02
STING agonists
bromophenol derivatives
cancer immunotherapy
Structure-based design of novel THR-β agonists and mechanism of activation research by molecular dynamics simulations
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 131, 页码: 15
作者:
Gao, Yang
;
Zhu, Haoran
;
Gao, Li-Xin
;
Xu, Gao-Ya
;
Lin, Jing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/12/04
Thyroid hormone receptor beta (THR-beta)
Agonists
Metabolic-associated steatohepatitis (MASH)
Molecular dynamics simulations
Design, synthesis, and biological activity of novel
para
-substituted phenylamino and phenyl derivatives of northebaine as selective delta opioid receptor agonists
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 130, 页码: 13
作者:
Zhang, Denggao
;
Gui, Jiangwen
;
Kong, Linghui
;
Hu, Chuyuan
;
Kou, Xinmeng
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/12/04
4,5-Epoxymorphinans
DOR-selective agonists
Structure-activity relationships
Discovery and optimization of novel indolecarboxylic acid derivative as potent glucagon-like peptide-1 receptor agonists
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 23
作者:
Zhao, Wanting
;
Yin, Yuqian
;
Shi, Zhuo
;
Yang, Ke
;
Li, Xinglin
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/07/25
GLP-1R
Agonists
hERG
Indolecarboxylic acid derivative
T2DM
Obesity
Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 16
作者:
Zheng, Jiefang
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2024/08/22
Triple reuptake inhibitors
5-HT 1A R agonists
Antidepressants
Multimodal serotonergic compounds
Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26, 页码: 10
作者:
Li, Jingru
;
You, Chongzhao
;
Li, Yang
;
Li, Changyao
;
Fan, Wenjia
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/08/22
SSTR5
peptide agonists
agonist selectivity
receptor activation
A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15
作者:
Sun, Kai
;
Zhu, Nan-lin
;
Huang, Su-ling
;
Qu, Hui
;
Gu, Yi-pei
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2024/07/12
nonalcoholic steatohepatitis
THR beta agonists
resmetirom
bile acids composition
intestinal lipid absorption
Update on the development of TGR5 agonists for human diseases
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 271, 页码: 20
作者:
Jin, Wangrui
;
Zheng, Mingyue
;
Chen, Yihua
;
Xiong, Hai
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2024/07/12
Bile acids
TGR5
T2DM
Gut-targeted TGR5 agonists
Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17
作者:
Zhu, Yueyue
;
Liu, Bo
;
Chen, Zonglong
;
Wang, Xianyang
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2023/12/08
Toll -like receptor 2/6 agonists
PamCS
Structure-activity relationship
Lipopeptide
Immunostimulants
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 17
作者:
Zhang, Ranran
;
Wang, Pengyu
;
Wei, Bingyan
;
Chen, Liang
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2023/10/17
ClpP agonists
Structure-activity relationship
Mitochondrial respiratory chain
Antileukemic therapy