机构

• 上海药物研究所 [13]
• 上海生物化学与细胞生... [3]
• 金属研究所 [2]
• 上海神经科学研究所 [2]
• 生物物理研究所 [1]
• 昆明植物研究所 [1]
• 更多

采集方式

• OAI收割 [23]

内容类型

• 期刊论文 [23]

发表日期

• 2021 [1]
• 2018 [2]
• 2017 [2]
• 2016 [1]
• 2015 [2]
• 2013 [4]
• 更多

学科主题

• Biochemist... [3]
• Neuroscien... [2]
• Cell Biolo... [1]
• Chemistry [1]
• Pharmacolo... [1]
• Science & ... [1]
• 更多

筛选

浏览/检索结果: 共23条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr 期刊论文  OAI收割 ORGANIC LETTERS, 2021, 卷号: 23, 期号: 2, 页码: 262-267 作者:  Tang,Xiao-Han;  Luo,Rong-Can;  Ye,Mao-Sen;  Tang,Hong-Yu;  Ma,Yuan-Liang   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/04/02 AMYLOID PRECURSOR PROTEIN  INSULIN-DEGRADING ENZYME  BETA-PROTEIN  GEMFIBROZIL  PREVENTION  SECRETASE  ADAM10  MEN   Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 177-183 作者:  Chen, Yu-ting;  Chen, Wu-yan;  Huang, Xiao-tian;  Xu, Ye-chun;  Zhang, Hai-yan   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 iron  neurons  amyloid precursor protein  sAPP alpha  beta-amyloid  beta-secretase  Alzheimer's disease   Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer 期刊论文  OAI收割 FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431 作者:  Wang, Xin;  Pei, Gang   |  收藏  |  浏览/下载：29/0  |  提交时间：2019/04/28 Amyloid Precursor Protein  Beta-secretase  App  Site  Cleavage  Adam10  Bace1  Localization  Dimerization  Endocytosis   Defining the minimum substrate and charge recognition model of gamma-secretase 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424 作者:  Yan, Yan;  Xu, Ting-Hai;  Melcher, Karsten;  Xu, H. Eric   |  收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Alzheimer's disease  amyloid beta (A beta)  amyloid precursor protein (APP)  C99, gamma-secretase  minimum substrate  Notch protein  recognition model   amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment 期刊论文  OAI收割 actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205 作者:  Chen Guofang;  Xu Tinghai;  Yan Yan;  Zhou Yuren;  Jiang Yi   |  收藏  |  浏览/下载：49/0  |  提交时间：2020/07/01 BLOOD-BRAIN-BARRIER  INSULIN-DEGRADING ENZYME  SOLID-STATE NMR  NICOTINIC ACETYLCHOLINE-RECEPTORS  METABOTROPIC GLUTAMATE RECEPTORS  ATOMIC-FORCE MICROSCOPY  GAMMA-SECRETASE COMPLEX  SMOOTH-MUSCLE-CELLS  AMELIORATES MEMORY IMPAIRMENT  ENDOTHELIN-CONVERTING ENZYME  amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery   A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2016, 卷号: 7, 期号: 4, 页码: 505-518 作者:  Yang, Shigao;  Liu, Wen;  Lu, Shuai;  Tian, Yong-zhen;  Wang, Wei-yun 收藏  |  浏览/下载：22/0  |  提交时间：2016/07/15 Amyloid-beta  camellikaempferoside B  beta-secretase  aggregation  neurotoxicity  microglia   A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease 期刊论文  OAI收割 REVIEWS IN THE NEUROSCIENCES, 2015, 卷号: 26, 期号: 1, 页码: 13-30 作者:  Guo, Xiaodan;  Jiang, Wei;  Li, Chenjing;  Zhu, Zhiyuan;  Shen, Xu   |  收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 acetyl cholinesterase  Alzheimer's disease  autophagy  beta-amyloid  ER stress  lifespan  multitarget  oxidative stress  secretase  tau protein   Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 11, 页码: 3344-3349 作者:  Dang, SY;  Wu, SJ;  Wang, JW;  Li, HB;  Huang, M 收藏  |  浏览/下载：22/0  |  提交时间：2015/07/22 intramembrane protease  Alzheimer's disease  PSH  gamma-secretase  beta-amyloid peptide   Microsecond molecular dynamics simulation of A beta(42) and identification of a novel dual inhibitor of A beta(42) aggregation and BACE1 activity 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9, 页码: 1243-1250 作者:  Wang, Yuan-yuan;  Li, Li;  Chen, Tian-tian;  Chen, Wu-yan;  Xu, Ye-chun   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 amyloid beta-peptide (A beta)  beta-secretase  Alzheimer's disease (AD)  dual inhibitor  structure-based virtual screening  molecular dynamics (MD) simulation   beta-Arrestin1 regulates gamma-secretase complex assembly and modulates amyloid-beta pathology 期刊论文  OAI收割 CELL RESEARCH, 2013, 卷号: 23, 期号: 3, 页码: 351-365 作者:  Liu, XS;  Zhao, XH;  Zeng, XL;  Bossers, K;  Swaab, DF 收藏  |  浏览/下载：35/0  |  提交时间：2015/07/22 Alzheimer's disease  beta-arrestin1  APH-1  gamma-secretase