机构

• 长春应用化学研究所 [4]
• 高能物理研究所 [3]
• 力学研究所 [2]
• 生物物理研究所 [2]
• 福建物质结构研究所 [2]
• 上海药物研究所 [2]
• 更多

采集方式

• OAI收割 [23]
• iSwitch采集 [1]

内容类型

• 期刊论文 [24]

发表日期

• 2025 [1]
• 2021 [1]
• 2019 [1]
• 2018 [2]
• 2016 [1]
• 2014 [1]
• 更多

学科主题

• Biochemist... [4]
• Biochemist... [1]
• Chemistry,... [1]
• Instrument... [1]

筛选

浏览/检索结果: 共24条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择作者升序作者降序发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序 Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24 作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/08/20 Voltage-gated sodium channel 1.8  Conformational restriction  Pharmacokinetic  Structure-activity relationship  Analgesic   Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2021, 卷号: 8 作者:     |  收藏  |  浏览/下载：69/0  |  提交时间：2021/11/01 cryo-EM structure  G protein-coupled receptor (GPCR)  partial and full agonists  conformational change  desensitization   Insights into the Mechanism of Quercetin against BSA-Fructose Glycation by Spectroscopy and High-Resolution Mass Spectrometry: Effect on Physicochemical Properties 期刊论文  OAI收割 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 1, 页码: 236-246 作者:  Zhang, L (Zhang, Lu)[ 1,2 ];  Lu, Y (Lu, Yu)[ 1,2 ];  Ye, YH (Ye, Yun-hua)[ 1,2 ];  Yang, SH (Yang, Si-hang)[ 1,2 ];  Tu, ZC (Tu, Zong-cai)[ 1,2,3 ]   |  收藏  |  浏览/下载：189/0  |  提交时间：2019/03/05 quercetin  glycation  BSA-fructose  conformational structure  Easy-nLC Q-Exactive MS/MS   Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (pdilt) provide insight into its chaperone activity 期刊论文  iSwitch采集 Journal of biological chemistry, 2018, 卷号: 293, 期号: 4, 页码: 1192-1202 作者:  Li, Huanhuan;  Yang, Kai;  Wang, Wenjia;  Niu, Yingbo;  Li, Jun 收藏  |  浏览/下载：79/0  |  提交时间：2019/04/23 Conformational change  Molecular chaperone  Protein structure  Small-angle x-ray scattering (saxs)  X-ray crystallography   Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 4, 页码: 1192-1202 作者:  Li, J   |  收藏  |  浏览/下载：58/0  |  提交时间：2019/09/24 conformational change  molecular chaperone  protein structure  small-angle X-ray scattering (SAXS)  X-ray crystallography   Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 卷号: 291, 期号: 11, 页码: 5740-5752 作者:  Deng, Xiangyu;  Qin, Xiangjing;  Chen, Lei;  Jia, Qian;  Zhang, Yonghui 收藏  |  浏览/下载：201/0  |  提交时间：2016/12/26 aminoacyl tRNA synthetase  Charcot-Marie-Tooth disease (CMT)  conformational change  crystal structure  enzyme mechanism   GPCR A(2A)AR Agonist Binding and Induced Conformation Changes of Functional Switches 期刊论文  OAI收割 chinese journal of chemical physics, 2014, 卷号: 27, 期号: 1, 页码: 29-38 作者:  Pang, Xue-qin;  Liu, Jian-yong 收藏  |  浏览/下载：34/0  |  提交时间：2015/11/17 A(2A) adenosine receptor  Molecular dynamics  Adenosine  Specific binding  Conformational dynamics  Ionic lock  Rotamer toggle switch  Secondary structure   Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations 期刊论文  OAI收割 nucleic acids research, 2013, 卷号: 41, 期号: 16, 页码: 7987-7996 Feng LY; Zhao AD; Ren JS; Qu XG 收藏  |  浏览/下载：21/0  |  提交时间：2014/04/15 CRYSTAL-STRUCTURE  TRIPLEX DNA  CONFORMATIONAL-CHANGES  CIRCULAR-DICHROISM  GENE-EXPRESSION  QUANTUM DOTS  BINDING  NANOTUBES  POLYMORPHISM  DERIVATIVES   Coil-to-rod conformational transition and single chain structure of graft copolymer by tuning the graft density 期刊论文  OAI收割 POLYMER, 2012, 卷号: 53, 期号: 4, 页码: 1005-1014 作者:  Liu, Wenyong;  Liu, Yuejun;  Zeng, Guangsheng;  Liu, Ruigang;  Huang, Yong   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/04/09 Coil-to-rod Conformational Transition  Single Chain Structure  Graft Copolymer   Appendant structure plays an important role in amyloidogenic cystatin dimerization prior to domain swapping 期刊论文  OAI收割 Journal of Biomolecular Structure & Dynamics, 2012, 卷号: 30, 期号: 1, 页码: 102-112 作者:  Yu YY;  Liu X(刘鑫);  He JW;  Zhang MY;  Li H 收藏  |  浏览/下载：45/0  |  提交时间：2012/12/04 chicken cystatin  conformational disease  cerebral-hemorrhage  crystal-structure  swiss-model  c variant  wild-type  protein  mutant  environment  molecular dynamic simulation  domain swapping  appendant structure  amyloidosis  hydrophobic core