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上海药物研究所 [3]
力学研究所 [1]
生物物理研究所 [1]
上海神经科学研究所 [1]
昆明植物研究所 [1]
海洋研究所 [1]
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OAI收割 [10]
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期刊论文 [10]
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2022 [1]
2018 [1]
2013 [1]
2012 [1]
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Biochemist... [3]
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A universal dual-readout viscosity flow sensor based on biotarget-triggered hyaluronidase release from aptamer-capped metal-organic frameworks
期刊论文
OAI收割
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 卷号: 372, 页码: 8
作者:
Wang, Yingwen
;
Zhang, Dun
;
Zeng, Yan
;
Sun, Yan
;
Qi, Peng
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2023/02/01
Dual-readout viscosity flow sensor
Aptamer-capped MOF
Biotarget triggered release
Cytochrome c
Hyaluronic acid hydrogel
Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis
期刊论文
OAI收割
Biochemical and biophysical research communications, 2018, 卷号: 500, 页码: 958-965
作者:
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2018/05/21
Mitochondrial dynamics
Different quality radiations
Release of cytochrome c
Apoptosis
Radiosensitivity
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption
期刊论文
OAI收割
journal of colloid and interface science, 2012, 卷号: 376, 页码: 312-321
Huang SS
;
Li CX
;
Cheng ZY
;
Fan Y
;
Yang PP
;
Zhang CM
;
Yang KY
;
Lin J
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2013/05/20
ORDERED MESOPOROUS SILICA
CONTROLLED-RELEASE
PORE-SIZE
FUNCTIONALIZED SBA-15
ENZYME IMMOBILIZATION
MOLECULAR-SIEVES
FACILE SYNTHESIS
CYTOCHROME-C
ADSORPTION
SPHERES
Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation
期刊论文
OAI收割
CELL DEATH AND DIFFERENTIATION, 2009, 卷号: 16, 期号: 12, 页码: 1694-1706
Shi, L
;
Wu, L
;
Wang, S
;
FAN, Z
;
范祖森
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2013/12/25
granzyme F
cytochrome c release
caspase inactivation
mitochondrial damage
ATP decline
Membrane Deformability and Membrane Tension of Single Isolated Mitochondria
期刊论文
OAI收割
Cellular And Molecular Bioengineering, 2008, 卷号: 1, 期号: 1, 页码: 67-74
作者:
Wang SQ(王世骐)
;
Jiang CS
;
Zhang Y(章燕)
;
Chen J(陈娟)
;
Wang B
收藏
  |  
浏览/下载:1029/129
  |  
提交时间:2009/08/03
Mechanical Properties
Physical-Chemical Environment
Respiratory State
Membrane Permeability Transition
Cytochrome-C
Oxidative-Phosphorylation
Permeability Transition
Mechanisms
Release
Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss
期刊论文
OAI收割
MOLECULAR AND CELLULAR BIOLOGY, 2006, 卷号: 26, 期号: 3, 页码: 1038-1050
Tao, YM
;
Yan, D
;
Yang, QY
;
Zeng, R
;
Wang, YZ
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2012/07/23
B TRANSCRIPTION FACTORS
CYTOCHROME-C RELEASE
BCL-X
IN-VITRO
LYMPHOCYTE-PROLIFERATION
SENSORY NEURONS
PROTEIN-KINASE
MICE LACKING
CELL-DEATH
ACTIVATION
apoptosisinitiatedbycarbontetrachlorideinmitochondriaofratprimaryculturedhepatocytes
期刊论文
OAI收割
actapharmacologicasinica, 2005, 卷号: 26, 期号: 8, 页码: 969
作者:
Cai Yan
;
Gong Likun
;
Qi Xinming
;
Li Xianghong
;
Ren Jin
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
CYTOCHROME-C
OXIDATIVE STRESS
ENDONUCLEASE-G
CELL-DEATH
LIVER
TOXICITY
PROTEINS
RELEASE
carbon tetrachloride
hepatocytes
mitochondria
caspase 3
cytochrome c