中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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A universal dual-readout viscosity flow sensor based on biotarget-triggered hyaluronidase release from aptamer-capped metal-organic frameworks 期刊论文  OAI收割
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 卷号: 372, 页码: 8
作者:  
Wang, Yingwen;  Zhang, Dun;  Zeng, Yan;  Sun, Yan;  Qi, Peng
  |  收藏  |  浏览/下载:37/0  |  提交时间:2023/02/01
Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis 期刊论文  OAI收割
Biochemical and biophysical research communications, 2018, 卷号: 500, 页码: 958-965
作者:  
  |  收藏  |  浏览/下载:40/0  |  提交时间:2018/05/21
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载:44/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption 期刊论文  OAI收割
journal of colloid and interface science, 2012, 卷号: 376, 页码: 312-321
Huang SS; Li CX; Cheng ZY; Fan Y; Yang PP; Zhang CM; Yang KY; Lin J
收藏  |  浏览/下载:16/0  |  提交时间:2013/05/20
Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation 期刊论文  OAI收割
CELL DEATH AND DIFFERENTIATION, 2009, 卷号: 16, 期号: 12, 页码: 1694-1706
Shi, L; Wu, L; Wang, S; FAN, Z; 范祖森
收藏  |  浏览/下载:17/0  |  提交时间:2013/12/25
Membrane Deformability and Membrane Tension of Single Isolated Mitochondria 期刊论文  OAI收割
Cellular And Molecular Bioengineering, 2008, 卷号: 1, 期号: 1, 页码: 67-74
作者:  
Wang SQ(王世骐);  Jiang CS;  Zhang Y(章燕);  Chen J(陈娟);  Wang B
收藏  |  浏览/下载:1029/129  |  提交时间:2009/08/03
Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss 期刊论文  OAI收割
MOLECULAR AND CELLULAR BIOLOGY, 2006, 卷号: 26, 期号: 3, 页码: 1038-1050
Tao, YM; Yan, D; Yang, QY; Zeng, R; Wang, YZ
收藏  |  浏览/下载:25/0  |  提交时间:2012/07/23
apoptosisinitiatedbycarbontetrachlorideinmitochondriaofratprimaryculturedhepatocytes 期刊论文  OAI收割
actapharmacologicasinica, 2005, 卷号: 26, 期号: 8, 页码: 969
作者:  
Cai Yan;  Gong Likun;  Qi Xinming;  Li Xianghong;  Ren Jin
  |  收藏  |  浏览/下载:18/0  |  提交时间:2020/07/01