中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [134]
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期刊论文 [432]
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Hydrogen, single-carbon compounds, and thermal regime in the oceanic ultramafic-dominated lithosphere: insights from a deep borehole on the Atlantis Massif
期刊论文
OAI收割
GEOCHIMICA ET COSMOCHIMICA ACTA, 2025, 卷号: 408, 页码: 84-104
作者:
Lang, Susan Q.
;
Wheat, C. Geoffrey
;
Dickerson, Kristin L.
;
Reagan, Mark K.
;
Savov, Ivan P.
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/12/09
Serpentinization
Hydrogen
Methane
Abiotic organic carbon
Organic acids
Ocean worlds
Prebiotic precursors
Formation waters
International Ocean Discovery Program
Expedition 399
Site 1601
Advancing active compound discovery for novel drug targets: insights from AI-driven approaches
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 12
作者:
Wang, Xing-you
;
Chen, Yang
;
Li, Yu-fan
;
Wei, Chao-yang
;
Liu, Meng-ya
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/08/20
AI-driven drug discovery
novel drug targets
molecular design
ligand exploration
phenotypic drug discovery
undruggable targets
Tectonics Modulated Long-Term Weathering Inputs From the East Asian Continent and Tropical Island Arc to the South China Sea Since the Late Oligocene
期刊论文
OAI收割
GEOPHYSICAL RESEARCH LETTERS, 2025, 卷号: 52, 期号: 10, 页码: 11
作者:
Li, Mengjun
;
Colin, Christophe
;
Wan, Shiming
;
Yu, Zhaojie
;
Jian, Zhimin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/21
silicate weathering
arc-continent collision
foraminiferal
epsilon
Nd
record
global cooling
South China Sea
International Ocean Discovery Program (IODP)
Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 119, 页码: 36
作者:
Wang, Han
;
Ma, Xiaolong
;
Sun, Longkang
;
Bi, Tongyu
;
Yang, Weibo
  |  
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2025/04/01
Synthetic methodologies
Medicinal chemistry
New chemical reactions
Anticancer drug discovery
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
;
Sun, Jin-yuan
;
Chen, Xue-qin
;
Wu, Hao-chen
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery
Synchrotron Radiation: A Key Tool for Drug Discovery
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 114, 页码: 10
作者:
Li, Fengcheng
;
Liu, Runze
;
Li, Wenjun
;
Xie, Mingyuan
;
Qin, Song
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2024/12/06
Synchrotron radiation
Drug discovery
Protein crystals
Structure determination
Ligand screening
Synchrotron Radiation: A Key Tool for Drug Discovery
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 114, 页码: 10
作者:
Li, Fengcheng
;
Liu, Runze
;
Li, Wenjun
;
Xie, Mingyuan
;
Qin, Song
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2024/12/06
Synchrotron radiation
Drug discovery
Protein crystals
Structure determination
Ligand screening
Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2024, 页码: 27
作者:
Zang, Yi
;
Sun, Ruo-nan
;
Feng, Ran-qi
;
Zhu, Hong-hui
;
Li, Xu-wen
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/12/25
Natural products
Terpenoids
Novel structures
Biological activity
Drug discovery
An updated patent review of SOS1 inhibitors (2022-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15
作者:
Zhou, Guizhen
;
Zhou, Chuan
;
Ma, Xinyi
;
Xu, Jiahang
;
Zhou, Zehui
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2024/12/11
SOS1
KRAS
cancer
inhibitor
drug discovery
The application of nanodiscs in membrane protein drug discovery & development and drug delivery
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2024, 卷号: 12
作者:
Dong, Yingkui
;
Tang, Huan
;
Dai, Han
;
Zhao, Hongxin
;
Wang, Junfeng
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/11/20
nanodisc (ND)
membrane protein
drug discovery & development
drug delievery
membrane scaffold protein (MSP)