中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [6]
采集方式
OAI收割 [6]
内容类型
期刊论文 [6]
发表日期
2024 [1]
2015 [1]
2013 [1]
2012 [2]
2008 [1]
学科主题
Biophysics [1]
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The effect of malaria-induced alteration of metabolism on piperaquine disposition in Plasmodium yoelii infected mice and predicted in malaria patients
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2024, 卷号: 64, 期号: 1, 页码: 11
作者:
Xie, Yuewu
;
Zhang, Yifan
;
Lin, Feifei
;
Chen, Xiaoyue
;
Xing, Jie
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/08/22
Malaria
Drug metabolizing enzymes
Piperaquine
Clearance
PBPK modelling
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
OAI收割
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Combinatorial Pharmacophore Modeling of Organic Cation Transporter 2 (OCT2) Inhibitors: Insights into Multiple Inhibitory Mechanisms
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2013, 卷号: 10, 期号: 12, 页码: 4611-4619
作者:
Xu, Yuan
;
Liu, Xian
;
Li, Shanshan
;
Zhou, Nannan
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
organic cation transporter 2 (OCT2)
drug clearance
drug-drug interaction (DDI)
pharmacophore
multiple inhibition mechanism
Assessment of Biliary Clearance in Early Drug Discovery Using Sandwich-Cultured Hepatocyte Model
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 卷号: 101, 期号: 5, 页码: 1898-1908
作者:
Pan, Guoyu
;
Boiselle, Carri
;
Wang, Jianling
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
biliary excretion
hepatobiliary disposition
drug interactions
in vitro-in vivo correlations (IVIVC)
hepatic clearance
permeability
transporters
hepatocytes
Role of transporters in hepatic drug disposition
期刊论文
OAI收割
Acta Pharmaceutica Sinica, 2012, 卷号: 47, 期号: 5, 页码: 565-572
作者:
Gao Chunying
;
Chen Xiaoyan
;
Zhong Dafang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
hepatic clearance
transporter
drug-drug interaction