中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
成都山地灾害与环境研... [1]
心理研究所 [1]
昆明植物研究所 [1]
自动化研究所 [1]
武汉岩土力学研究所 [1]
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OAI收割 [10]
内容类型
期刊论文 [10]
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2024 [1]
2023 [1]
2021 [3]
2019 [1]
2017 [2]
2014 [1]
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In silico off-target profiling for enhanced drug safety assessment
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 7, 页码: 2927-2941
作者:
Liu, Jin
;
Gui, Yike
;
Rao, Jingxin
;
Sun, Jingjing
;
Wang, Gang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/08/22
Drug safety
Off-target prediction
Adverse drug reactions
Toxicity
Molecular representation
Artificial intelligence
BARN: Behavior-Aware Relation Network for multi-label behavior detection in socially housed macaques
期刊论文
OAI收割
ZOOLOGICAL RESEARCH, 2023, 卷号: 44, 期号: 6, 页码: 1026-1038
作者:
Yang, Sen
;
Chen, Zhi-Yuan
;
Liang, Ke-Wei
;
Qin, Cai-Jie
;
Yang, Yang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/02/22
Macaque behavior
Drug safety
assessment
Multi-label behavior detection
Behavioral
similarity
Relation network
Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 90, 页码: 19
作者:
Bolarin, Joshua Adedeji
;
Oluwatoyosi, Mercy Adaramodu
;
Orege, Joshua Iseoluwa
;
Ayeni, Emmanuel Ayodeji
;
Ibrahim, Yusuf Ajibola
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/03/29
COVID-19
Therapeutics
Drug interaction
Antiviral drugs
Health and safety
Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 90, 页码: 19
作者:
Bolarin, Joshua Adedeji
;
Oluwatoyosi, Mercy Adaramodu
;
Orege, Joshua Iseoluwa
;
Ayeni, Emmanuel Ayodeji
;
Ibrahim, Yusuf Ajibola
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/25
COVID-19
Therapeutics
Drug interaction
Antiviral drugs
Health and safety
p Metabolite Identification in the Preclinical and Clinical Phase of Drug Development
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 11, 页码: 838-857
作者:
Wu, Yali
;
Pan, Lulu
;
Chen, Zhendong
;
Zheng, Yuandong
;
Diao, Xingxing
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
Metabolite identification
drug toxicity
drug exposure
covalent-binding drug
drug safety
natural medicines
Pharmacokinetics and safety evaluation in healthy Chinese volunteers of alkaloids from leaf of Alstonia scholaris: A multiple doses phase I clinical trial
期刊论文
OAI收割
PHYTOMEDICINE, 2019, 卷号: 61, 页码: 13
作者:
Li, Rui
;
Zi, Ming-Jie
;
Gou, Zhong-Ping
;
Zhao, Yun-Li
;
Zhang, Wan-Tong
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/03/17
Capsule of alkaloids from leaf of A. scholaris (CALAS)
Pharmacokinetics
Safety evaluation
Drug re-excitation research
Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
  |  
收藏
  |  
浏览/下载:148/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns
期刊论文
OAI收割
FRONTIERS IN PSYCHOLOGY, 2017, 卷号: 8, 期号: 0, 页码: 1-17
作者:
Zhao, Haichao
;
Qiao, Lei
;
Fan, Dongqiong
;
Zhang, Shuyue
;
Turel, Ofir
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2017/07/10
transcranial direct current stimulation (tDCS)
drug addiction
Alzheimer's disease
major depression disorder
safety
decision neuroscience
cognitive neuroscience
effectsofanal3andmg2containingantacidferroussulfateandcalciumcarbonateontheabsorptionofnemonoxacintg873870inhealthychinesevolunteers
期刊论文
OAI收割
actapharmacologicasinica, 2014, 卷号: 35, 期号: 12, 页码: 1586
作者:
Zhang Yifan
;
Dai Xiaojian
;
Wang Ting
;
Chen Xiaoyan
;
Li Liang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
NON-FLUORINATED QUINOLONE
CIPROFLOXACIN
GATIFLOXACIN
PHARMACOKINETICS
BIOAVAILABILITY
ALUMINUM
SAFETY
SLEEP
nemonoxacin
nonfluorinated quinolone
drug-drug interaction
antacid
ferrous sulfate
calcium carbonate
drug absorption
clinical pharmacokinetics
A Discussion on improvement of toxicological patholoy study
期刊论文
OAI收割
Bulletin of National Natural Science Foundation of China, 2003, 卷号: 17, 期号: 1, 页码: 34-37
作者:
Ren Jin
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Drug safety assessment
Toxicological pathology
Immunotoxicology evaluation
Short-term replacement model
Highthroughput toxicology