机构

• 上海药物研究所 [5]
• 上海生物化学与细胞生... [3]
• 上海神经科学研究所 [2]
• 过程工程研究所 [1]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2017 [2]
• 2016 [1]
• 2015 [1]
• 2013 [1]
• 2012 [1]
• 2011 [1]
• 更多

学科主题

• Cell Biolo... [2]
• Biochemist... [1]
• Biophysics [1]
• Neuroscien... [1]
• Science & ... [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Defining the minimum substrate and charge recognition model of gamma-secretase 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424 作者:  Yan, Yan;  Xu, Ting-Hai;  Melcher, Karsten;  Xu, H. Eric   |  收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Alzheimer's disease  amyloid beta (A beta)  amyloid precursor protein (APP)  C99, gamma-secretase  minimum substrate  Notch protein  recognition model   amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment 期刊论文  OAI收割 actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205 作者:  Chen Guofang;  Xu Tinghai;  Yan Yan;  Zhou Yuren;  Jiang Yi   |  收藏  |  浏览/下载：49/0  |  提交时间：2020/07/01 BLOOD-BRAIN-BARRIER  INSULIN-DEGRADING ENZYME  SOLID-STATE NMR  NICOTINIC ACETYLCHOLINE-RECEPTORS  METABOTROPIC GLUTAMATE RECEPTORS  ATOMIC-FORCE MICROSCOPY  GAMMA-SECRETASE COMPLEX  SMOOTH-MUSCLE-CELLS  AMELIORATES MEMORY IMPAIRMENT  ENDOTHELIN-CONVERTING ENZYME  amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery   Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio 期刊论文  OAI收割 CELL DISCOVERY, 2016, 卷号: 2 作者:  Xu, Ting-Hai;  Yan, Yan;  Kang, Yanyong;  Jiang, Yi;  Melcher, Karsten   |  收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Alzheimer's disease  C99  gamma-secretase  familial Alzheimer disease (FAD)-linked mutations  epsilon-cleavage assay   Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 11, 页码: 3344-3349 作者:  Dang, SY;  Wu, SJ;  Wang, JW;  Li, HB;  Huang, M 收藏  |  浏览/下载：23/0  |  提交时间：2015/07/22 intramembrane protease  Alzheimer's disease  PSH  gamma-secretase  beta-amyloid peptide   beta-Arrestin1 regulates gamma-secretase complex assembly and modulates amyloid-beta pathology 期刊论文  OAI收割 CELL RESEARCH, 2013, 卷号: 23, 期号: 3, 页码: 351-365 作者:  Liu, XS;  Zhao, XH;  Zeng, XL;  Bossers, K;  Swaab, DF 收藏  |  浏览/下载：35/0  |  提交时间：2015/07/22 Alzheimer's disease  beta-arrestin1  APH-1  gamma-secretase   A Peptide Binding to the beta-Site of APP Improves Spatial Memory and Attenuates A beta Burden in Alzheimer's Disease Transgenic Mice 期刊论文  OAI收割 PLOS ONE, 2012, 卷号: 7, 期号: 11, 页码: 文献号: e48540 作者:  Yang, Shi-gao;  Wang, Shao-wei;  Zhao, Min;  Zhang, Ran;  Zhou, Wei-wei 收藏  |  浏览/下载：27/0  |  提交时间：2013/10/11 AMYLOID PRECURSOR PROTEIN  CLEAVING ENZYME-1 BACE1  LONG-TERM POTENTIATION  SINGLE-CHAIN ANTIBODY  GAMMA-SECRETASE  MOUSE MODEL  THERAPEUTIC TARGET  ALPHA-SECRETASE  CELL BIOLOGY  IN-VITRO   Research progress about the regulation of GXXXG structures in the Alzheimer-related protein 期刊论文  OAI收割 Chinese Pharmacological Bulletin, 2011, 卷号: 27, 期号: 1, 页码: 1-4 作者:  Wu Yanlin;  Xin Xiaojie;  Xin Xianliang;  Geng Meiyu   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 GXXXG structure  Abeta production  Abeta aggregation  Alzheimer's disease  APP  gamma-secretase complex   Regulation of beta cleavage of amyloid precursor protein 期刊论文  OAI收割 NEUROSCIENCE BULLETIN, 2010, 卷号: 26, 期号: 5, 页码: 417-427 Wang, Jun-Feng; Lu, Rui; Wang, Yi-Zheng 收藏  |  浏览/下载：19/0  |  提交时间：2012/07/13 Alzheimer's disease  amyloid beta peptide  amyloid precursor protein  beta secretase  APP TRANSGENIC MICE  ALZHEIMERS-DISEASE  A-BETA  SECRETASE ACTIVITY  PLAQUE-FORMATION  GAMMA-SECRETASE  GENE-EXPRESSION  IN-VIVO  BACE1  BRAIN   A GPCR/secretase complex regulates beta- and gamma-secretase specificity for A beta production and contributes to AD pathogenesis 期刊论文  OAI收割 CELL RESEARCH, 2010, 卷号: 20, 期号: 2, 页码: 138-153 作者:  Teng, L;  Zhao, J;  Wang, FF;  Ma, L;  Pei, G 收藏  |  浏览/下载：26/0  |  提交时间：2015/07/22 G protein-coupled receptor  Alzheimer's disease  BACE  gamma-secretase  Notch   Development of a High-Throughput Assay for Screening of gamma-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila gamma-Secretase 期刊论文  OAI收割 MOLECULES, 2009, 卷号: 14, 期号: 9, 页码: 3589-3599 作者:  Wang, Lie-Feng;  Zhang, Ru;  Xie, Xin   |  收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 gamma-secretase inhibitor  fluorogenic substrate  high throughput screening