机构

• 上海药物研究所 [64]
• 上海神经科学研究所 [20]
• 上海生物化学与细胞... [15]
• 昆明植物研究所 [13]
• 金属研究所 [8]
• 上海营养与健康研究所 [8]
• 更多

采集方式

• OAI收割 [166]
• iSwitch采集 [5]

内容类型

• 期刊论文 [171]

发表日期

• 2024 [4]
• 2023 [3]
• 2022 [5]
• 2021 [4]
• 2020 [8]
• 2019 [6]
• 更多

学科主题

• Neuroscie... [13]
• Cell Biol... [11]
• Biochemist... [9]
• Oncology [7]
• Pharmacolo... [6]
• Chemistry [4]
• 更多

筛选

浏览/检索结果: 共171条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d] pyrimidines as potent HPK1 kinase inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 119, 页码: 13 作者:  Wu, Feifei;  Li, Huiyu;  Li, Weiqiang;  Zhang, Laishun;  An, Qi   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/04/01 Optimization  Hematopoietic progenitor kinase 1  Inhibitor  Cancer immunotherapy   Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13 作者:  Tang, Mingze;  Zhou, Xuan;  Shen, Qianqian;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/08/22 Receptor -interacting protein kinase 1  Histone deacetylases  Inhibitor  Molecular dynamics (MD) simulation  ADMET analysis   Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 16 作者:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/12/25 inhibitor  pharmacokinetic study  pyridazin-4-one  receptor-interacting protein kinase 1  selectivity   Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 21 作者:  Lan, Yaohan;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Geng, Meiyu   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/08/22 autoimmune disease  necroptosis inhibitor  pharmacokinetic profile  receptor interacting protein kinase 1 (RIPK1)  structural optimization   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16 作者:  Chen, Yun;  Ning, Yi;  Chen, Zhiwei;  Xue, Yaping;  Wu, Qingyun   |  收藏  |  浏览/下载：24/0  |  提交时间：2023/10/17 Apoptosis  Diffuse large B-Cell lymphoma  Interleukin-1 receptor associated kinase 4  Structure-based drug design  2  3-Dihydrobenzofuran   Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者:  Wu, Feifei;  Li, Huiyu;  An, Qi;  Sun, Yaoliang;  Yu, Jinghua   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/10/17 Hematopoietic progenitor kinase 1 (HPK1)  Cancer immunotherapy  Inhibitor  T cell   治疗特应性皮炎口服新药abrocitinib 期刊论文  OAI收割 中国新药杂志, 2023, 卷号: 32, 期号: 3, 页码: 241 作者:  周映红;  王春丽;  邓宏勇   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/05/22 abrocitinib  small molecule  Janus kinase-1 inhibitor  atopic dermatitis  abrocitinib  小分子  Janus激酶-1抑制剂  特应性皮炎   Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243 作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang   |  收藏  |  浏览/下载：56/0  |  提交时间：2022/12/23 CSF1R inhibitor  Kinase inhibitor  Macrophage polarization   A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1 beta and IL-6 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 11, 页码: 4180-4192 作者:  Liao, Liping;  Dang, Wenzhen;  Lin, Tingting;  Yu, Jinghua;  Liu, Tonghai   |  收藏  |  浏览/下载：31/0  |  提交时间：2023/04/10 Glycolysis  Phosphoglycerate kinase 1  Macrophages  NRF2  Inflammation