中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海神经科学研究所 [8]
水生生物研究所 [7]
上海药物研究所 [5]
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合肥物质科学研究院 [4]
大连化学物理研究所 [2]
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期刊论文 [46]
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Structural Basis of Main Proteases of Coronavirus Bound to Bofutrelvir
期刊论文
OAI收割
JOURNAL OF MOLECULAR BIOLOGY, 2024, 卷号: 436, 期号: 22, 页码: 16
作者:
Wang, Wei-wei
;
Zeng, Pei
;
Liu, Tongchao
;
Zhou, Xue-lan
;
Lin, Cheng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/21
SARS-CoV-2
Coronavirus
Main protease
Mutants
Inhibitor
Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Ka)
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023, 卷号: 1878, 期号: 5, 页码: 6
作者:
Vogt, Peter K.
;
Hart, Jonathan R.
;
Yang, Su
;
Zhou, Qingtong
;
Yang, Dehua
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Phosphoinositide 3-kinase
BYL-719
Nanobody
CXMS
Mutants
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 46, 页码: 11
作者:
Liu, Xiao
;
Zhou, Qingtong
;
Hart, Jonathan R.
;
Xu, Yingna
;
Yang, Su
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/10/17
phosphoinositide 3-kinase (PI3K)
mass spectrometry
mutants
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
High level of reactive oxygen species inhibits triacylglycerols accumulation in Chlamydomonas reinhardtii
期刊论文
OAI收割
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2019, 卷号: 38, 页码: 13
作者:
Miao, Rongli
;
Ma, Xiaocui
;
Deng, Xuan
;
Huang, Kaiyao
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/07/01
Chlamydomonas
Lipid droplets (LDs)
Reactive oxygen species (ROS)
Glutathione peroxidase (GPX)
Mutants
A genome-wide view of mutations in respiration-deficient mutants of Saccharomyces cerevisiae selected following carbon ion beam irradiation
期刊论文
OAI收割
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 卷号: 103, 页码: 1851-1864
作者:
Guo, Xiaopeng
;
Zhang, Miaomiao
;
Gao, Yue
;
Cao, Guozhen
;
Yang, Yang
  |  
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2019/04/02
Saccharomyces cerevisiae
Carbon ion beam irradiation
Respiration-deficient mutants
Genome-wide resequencing
Molecular mutation spectrum
Mitochondrial genome
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
期刊论文
OAI收割
CANCER LETTERS, 2019, 页码: 105-114
作者:
Lu, Tingting
;
Chen, Cheng
;
Wang, Aoli
;
Jiang, Zongru
;
Qi, Ziping
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/14
cKIT T670I mutant
Activation loop mutants
Drug resistance
Recovery of the non-functional EGFP-assisted identification of mutants generated by CRISPR/Cas9
期刊论文
OAI收割
PLANT CELL REPORTS, 2019, 卷号: 38, 期号: 12, 页码: 1541-1549
作者:
Ren, Chong
;
Guo, Yuchen
;
Gathunga, Elias Kirabi
;
Duan, Wei
;
Li, Shaohua
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2022/01/06
Selection of mutants
CRISPR
Cas9
Non-functional EGFP
Reporter gene
Improvement of multiplex semi-nested PCR system for screening of rare mutations by high-throughput sequencing
期刊论文
OAI收割
BIOTECHNIQUES, 2019, 卷号: 67, 期号: 6, 页码: 294-298
作者:
Zhang, Yingchun
;
Chi, Xu
;
Feng, Laibao
;
Wu, Xingwen
;
Qi, Xiaoquan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/06
dilution
improvement
multiplexed target enrichment
mutants
next generation sequencing
Hepatitis b virus infection: defective surface antigen expression and pathogenesis
期刊论文
iSwitch采集
World journal of gastroenterology, 2018, 卷号: 24, 期号: 31, 页码: 3488-3499
作者:
Wu, Chun-Chen
;
Chen, Ying-Shan
;
Cao, Liang
;
Chen, Xin-Wen
;
Lu, Meng-Ji
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/05/08
Hepatitis b surface protein
Defective surface antigen mutants
Endoplasmic reticulum stress
Fulminant hepatitis b
Occult hepatitis b virus infection
Pathogenesis